Xu Guo¹, Yanan Yu², Xiaolin Ma³, Yuanjie Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069274 - 30 December 2025

Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic trait of PAN3-AS1 across pan-cancer comprehensively. Methods: We studied the diagnostic and prognostic features and the immune landscape of PAN3-AS1 across pan-cancer by bioinformatics approaches. The hierarchical regulatory networks governing PAN3-AS1 expression in colon cancer were explored via chromatin immunoprecipitation, luciferase activity assays, and RNA immunoprecipitation, etc. We screened drugs sensitive to WAP four-disulfide core domain 13 (WFDC13) by virtual screening and molecular docking. Results: Single-cell transcriptomics demonstrated that a variety of immune populations abnormally expressed PAN3-AS1… More >

Zhengqiang Peng^1,*, Rendong Feng¹, Fang Han¹, Jing Guo¹, Shen Chi¹, Wenao Huang¹, Jie Luo²

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2945-2961, 2025, DOI:10.32604/fdmp.2025.073281 - 31 December 2025

Abstract Jet pumps often suffer from efficiency losses due to the intense mixing of power and suction fluids, which leads to significant kinetic energy dissipation. Enhancing the efficiency of such pumps requires careful optimization of their structural parameters. In this study, a computational fluid dynamics (CFD) model of a hydraulic jet sand-flushing pump is developed to investigate the effects of throat-to-nozzle distance, area ratio, and throat length on the pump’s sand-carrying performance. An orthogonal experimental design is employed to optimize the structural parameters, while the influence of sand characteristics on pumping performance is systematically evaluated. Complementary… More >

Ruiqi Li^1,2, Hongda Chen^1,2,*, Haixiao Hu^1,2,3, Yu Zhang², Shuxin Li^1,2,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.011327

Abstract Composite hydrogen cylinders are recognized as the most efficient solution for storage and transportation of high-pressure gaseous hydrogen. The plastic-lined and fully carbon fiber-wound Type IV composite cylinders are one of the most attractive advanced hydrogen storage technologies. The design of carbon fiber reinforcements on the dome section of the cylinder is one of the critical challenges in the development of Type IV composite hydrogen cylinders. Conventional design approaches ignored the variable angle of fiber-wound layers and the influence of fiber angle and thickness variations in the dome section on design and often result in… More >

Wenjie Zhou^#, Jiawei Ding^#, Danfeng Xu^*

Oncology Research, Vol.33, No.11, pp. 3493-3522, 2025, DOI:10.32604/or.2025.066783 - 22 October 2025

Abstract Objectives: Despite the fact that prostate cancer is one of the most common tumors in men, this study intends to evaluate the predictive significance of immune and metabolic genes in prostate cancer using multi-omics data and experimental validation. Methods: The research developed and validated a prognostic model utilizing The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, integrating immune and metabolic gene sets. Additionally, the prognostic gene Adenylate Kinase 5 (AK5) was analyzed in prostate cancer tissue microarrays from Ruijin Hospital. The functional role of the AK5 gene was validated through knockdown and… More >

Tayfun Abut^*

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 4023-4042, 2025, DOI:10.32604/cmc.2025.066920 - 23 September 2025

Abstract In this study, a dynamic model for an inverted pendulum system (IPS) attached to a car is created, and two different control methods are applied to control the system. The designed control algorithms aim to stabilize the pendulum arms in the upright position and the car to reach the equilibrium position. Grey Wolf Optimization-based Linear Quadratic Regulator (GWO-LQR) and GWO-based Fuzzy LQR (FLQR) control algorithms are used in the control process. To improve the performance of the LQR and FLQR methods, the optimum values of the coefficients corresponding to the foot points of the membership… More >

Wenda Ma, Qizhi Tang^*, Huang Lei, Longfei Chang, Chen Wang

Structural Durability & Health Monitoring, Vol.19, No.5, pp. 1265-1286, 2025, DOI:10.32604/sdhm.2025.065294 - 05 September 2025

Abstract Lost acceleration response reconstruction is crucial for assessing structural conditions in structural health monitoring (SHM). However, traditional methods struggle to address the reconstruction of acceleration responses with complex features, resulting in a lower reconstruction accuracy. This paper addresses this challenge by leveraging the advanced feature extraction and learning capabilities of fully convolutional networks (FCN) to achieve precise reconstruction of acceleration responses. In the designed network architecture, the incorporation of skip connections preserves low-level details of the network, greatly facilitating the flow of information and improving training efficiency and accuracy. Dropout techniques are employed to reduce… More >

XIANG LI^1,#, WENKE JIN^2,#, LIFENG WU², HUAN WANG¹, XIN XIE¹, WEI HUANG^1,*, BO LIU^2,*

Oncology Research, Vol.33, No.1, pp. 67-81, 2025, DOI:10.32604/or.2024.055921 - 20 December 2024

Abstract Background: Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways. Methods: Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI… More >

ZHILI ZHUO^#, DONGNI ZHANG^#, WENPING LU^*, XIAOQING WU, YONGJIA CUI, WEIXUAN ZHANG, MENGFAN ZHANG

Oncology Research, Vol.32, No.6, pp. 1093-1107, 2024, DOI:10.32604/or.2024.047257 - 23 May 2024

Abstract Breast cancer is the leading cause of cancer-related deaths in women worldwide, with Hormone Receptor (HR)+ being the predominant subtype. Tamoxifen (TAM) serves as the primary treatment for HR+ breast cancer. However, drug resistance often leads to recurrence, underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence rates. Artemisinin (ART) has demonstrated efficacy in inhibiting the growth of drug-resistant cells, positioning art as a viable option for counteracting endocrine resistance. This study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental… More > Graphic Abstract

JIAN TANG¹, CHENQIANG ZHU¹, YUN CHEN¹, YUNLONG WU¹, MING HE¹, YI ZHOU², MINGHUA XIE^2,*

BIOCELL, Vol.48, No.4, pp. 639-651, 2024, DOI:10.32604/biocell.2024.047562 - 09 April 2024

Abstract Background: The specific impact of sphingolipid metabolism on developing hepatocellular Carcinoma (HCC) remains unclear. This study aims to explore the relationship between sphingolipid metabolism and HCC prognosis, immune response, and drug sensitivity. Methods: Data were obtained from The Cancer Genome Atlas (TCGA)-Hepatocellular Carcinoma (LIHC) and Gene Expression Omnibus (GEO, GSE14520 datasets). 47 sphingolipid metabolism genes were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. After classifying HCC samples using the Non-negative Matrix Factorization (NMF) clustering method, differentially expressed genes were screened. Then, 8 risk genes were obtained by univariate analysis, survival random forest… More > Graphic Abstract

YANAN MA¹, SHANSHAN WANG^2,*, HUIGUO DING^1,*

BIOCELL, Vol.48, No.3, pp. 463-471, 2024, DOI:10.32604/biocell.2024.048244 - 15 March 2024

Abstract Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis and high mortality worldwide. Although cystathionine-gamma-lyase (CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive. Methods: In our study, the CSE expression in HCC was analyzed in Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) datasets and further confirmed by RT-qPCR and immunohistochemistry assays in HCC samples. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated… More >