Phuong-Thao Nguyen-Thi1, Quoc Phong Le1, Volker R. Stoldt2, Ngoc Quyen Tran3,4, Anh Tho Le5, Khon Huynh1,*
Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 113-118, 2020, DOI:10.32604/mcb.2020.09643
Abstract Fibrillar fibronectin (FFN) is a biological active form of FN which form
linear and branched meshwork around cells and support cellular activities. Previous studies have demonstrated that shear stress can induce cell-free FN fibrillogenesis. In this study, we further examined the effect of shear stress conditions on
morphology of formed FFN and preliminarily looked for relationship between
FFN’s morphology and cell adhesion. Plasma FN at 50 µg/ml was perfused
through channel slides at shear rates of 500 s-1 or 4000 s-1. Our results showed
that there were four FFN structures formed: (1) FN nodules, (2) fibril in different
sizes (3)… More >
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