Wenhui Hu1, Yun Wang1, Jin Chen1, Yonggang Song1, Jinhua Long1, Zhu Zeng1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 67-67, 2019, DOI:10.32604/mcb.2019.07083
Abstract The responses of dendritic cells (DCs) to the mechanical microenvironment caused by implanted materials are highly correlated to the host immune responses and largely determines the outcome of tissue regeneration [1,2]. In the early stage of the inflammations following injury or implantation, a large amount of fibrin would deposit around the implanted materials and form a microporous fibrous-liked network structure, which can provide mechanical microenvironment with different spatial confinement in dimensions for following recruited DCs. Herein, we have established a useful model by salmon fibrin to mimic the deposited fibrin matrix and found that DCs cultured on or in fibrin… More >
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