Dawei Song1,*, Nicholas Hugenberg2, Assad A Oberai1
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 45-45, 2019, DOI:10.32604/mcb.2019.07138
Abstract Tractions exerted by cells on the extracellular matrix (ECM) are critical in many important physiological and pathological processes such as embryonic morphogenesis, cell migration, wound healing, and cancer metastasis. Traction Force Microscopy (TFM) is a robust tool to quantify cellular tractions during cell-matrix interactions. It works by measuring the motion of fiducial markers inside the ECM in response to cellular tractions and using this information to infer the traction field. Most applications of this technique have heretofore assumed that the ECM is homogeneous and isotropic [1], although the native ECM is typically composed of fibrous networks, and thus heterogeneous and… More >
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