Wei Huang∗,†, Yi Wah Mak*, Peter C. Y. Chen‡§
Molecular & Cellular Biomechanics, Vol.8, No.2, pp. 91-104, 2011, DOI:10.3970/mcb.2011.008.091
Abstract A molecular configuration tensor Pij was introduced to analyze the distribution of fibrous proteins in vascular cells for studying cells and tissues biomechanics. We have used this technique to study the biomechanics of vascular remodeling in response to the changes of blood pressure and flow. In this paper, the remodeling of the geometrical arrangement of F-actin fibers in the smooth muscle cells in rat's pulmonary arteries in hypoxic hypertension was studied. The rats were exposed to a hypoxia condition of 10% for 0, 2, 12, and 24 hr at sea level. Remodeling of blood vessels were studied at the in… More >
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