R. Ani^1,*, O. S. Deepa², B. R. Manju¹

Computer Systems Science and Engineering, Vol.47, No.3, pp. 3033-3048, 2023, DOI:10.32604/csse.2023.033807

Abstract The drug development process takes a long time since it requires sorting through a large number of inactive compounds from a large collection of compounds chosen for study and choosing just the most pertinent compounds that can bind to a disease protein. The use of virtual screening in pharmaceutical research is growing in popularity. During the early phases of medication research and development, it is crucial. Chemical compound searches are now more narrowly targeted. Because the databases contain more and more ligands, this method needs to be quick and exact. Neural network fingerprints were created more effectively than the well-known… More >

Zhiguo Lu¹, Yuhong Zheng^1,*, Pengchong Zhang², Boyuan Fan³, Aimin Yu⁴, Li Fu^3,*

Phyton-International Journal of Experimental Botany, Vol.91, No.11, pp. 2549-2558, 2022, DOI:10.32604/phyton.2022.021288

Abstract In this communication, we used electrochemical sensor for recording the electrochemical profiles of eleven species of Yulania spp. from leaf extract. Two solvents and two buffer conditions were used for electrochemical fingerprints collection. Their electrochemical fingerprints can be converted to different patterns and consequently for species recognition. The results indicate the pattern recognition is much convenient than that of the recognition of species directly using voltammetric signal. The current information in electrochemical fingerprinting represents the type and amount of electrochemically active molecules, which linked to the genetic differences among the plants. Therefore, the electrochemical fingerprints were applied for further phylogenetic… More >

Jian Zhao^*1, Xia Zhang^†1, Xiaonan Cui^*, Di Wang^*, Bin Zhang^*‡, Liying Ban^*

Oncology Research, Vol.28, No.1, pp. 103-106, 2020, DOI:10.3727/096504019X15605078731913

Abstract Hand–foot syndrome (HFS) is the main side effect of capecitabine and affects the compression zones of the body such as the palms and soles, causing numbness, paresthesias, skin swelling or erythema, scaling, chapping, hard nodule-like blisters, and severe pain. Loss of fingerprints is also observed in some cases. Severe cases of HFS are common in the review of clinical reports. However, loss of fingerprints has not received significant attention. Two reported cases of loss of fingerprints in The New England Journal of Medicine and The BMJ have drawn attention to this side effect of capecitabine. Loss of fingerprints has a… More >

Yuhao Chen¹, Jiajun Liu¹, Yaxi Peng¹, Ziyi Liu², Zhipeng Yang^1,*

Intelligent Automation & Soft Computing, Vol.33, No.3, pp. 1501-1516, 2022, DOI:10.32604/iasc.2022.026346

Abstract As a neural fingerprint, functional connectivity networks (FCNs) have been used to identify subjects from group. However, a number of studies have only paid attention to cerebral cortex when constructing the brain FCN. Other areas of the brain also play important roles in brain activities. It is widely accepted that the human brain is composed of many highly complex functional networks of cortex. Moreover, recent studies have confirmed correlations between signals of cortex and white matter (WM) bundles. Therefore, it is difficult to reflect the functional characteristics of the brain through a single-layer FCN. In this paper, a multilayer FCN… More >

K. Y. Volokh^*

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 107-135, 2013, DOI:10.3970/mcb.2013.010.107

Abstract The application of mechanics to biology – biomechanics – bears great challenges due to the intricacy of living things. Their dynamism, along with the complexity of their mechanical response (which in itself involves complex chemical, electrical, and thermal phenomena) makes it very difficult to correlate empirical data with theoretical models. This difficulty elevates the importance of useful biomechanical theories compared to other fields of engineering. Despite inherent imperfections of all theories, a well formulated theory is crucial in any field of science because it is the basis for interpreting observations. This is all-the-more vital, for instance, when diagnosing symptoms, or… More >