Andrew Scarborough1, Yvoni Kyriakidou1, Derek C. Lee2, Tomás Duraj2, Thomas N. Seyfried2, Isabella D. Cooper1,*
BIOCELL, Vol.50, No.6, 2026, DOI:10.32604/biocell.2026.074152
- 09 June 2026
Abstract The global rise in chronic, non-communicable diseases (NCDs) is inextricably linked to metabolic dysfunction, with hyperinsulinaemia acting as a potent upstream driver of ageing and age-related disease. Some of the most burdensome diseases of our time, including type 2 diabetes, cardiovascular disease, cancer, and neurodegenerative conditions, such as Alzheimer’s disease (AD), are largely underpinned by insulin resistance as part of a broader system of metabolic and mitochondrial dysfunction. These pathologies are particularly pronounced in the developed world, where obesity and other lifestyle-related conditions are major contributors to disease burden and premature mortality. As an upstream… More >