Zhen Wang¹, Yi Sui¹, Wen Wang¹, Dominique Barthѐs-Biesel², Anne-Virginie Salsac^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 42-43, 2019, DOI:10.32604/mcb.2019.07148

Abstract Capsules are liquid droplets enclosed by a thin membrane which can resist shear deformation. They are widely found in nature (e.g. red blood cells) and in numerous applications (e.g. food, cosmetic, biomedical and pharmaceutical industries [1]), where they often flow through a complicated network of tubes or channels: this is the case for RBCs in the human circulation or for artificial capsules flowing through microfluidic devices. Central to these flows is the dynamic motion of capsules at bifurcations, in particular the question of path selection. A good understanding of this problem is indeed needed to elucidate some intriguing phenomena in… More >

Jie Cheng¹, Feimi Yu¹, Lucy T. Zhang^{1, *}

CMES-Computer Modeling in Engineering & Sciences, Vol.119, No.1, pp. 91-124, 2019, DOI:10.32604/cmes.2019.04318

Abstract We present a high performance modularly-built open-source software - OpenIFEM. OpenIFEM is a C++ implementation of the modified immersed finite element method (mIFEM) to solve fluid-structure interaction (FSI) problems. This software is modularly built to perform multiple tasks including fluid dynamics (incompressible and slightly compressible fluid models), linear and nonlinear solid mechanics, and fully coupled fluid-structure interactions. Most of open-source software packages are restricted to certain discretization methods; some are under-tested, under-documented, and lack modularity as well as extensibility. OpenIFEM is designed and built to include a set of generic classes for users to adapt so that any fluid and… More >

Xueying Huang^*, Chun Yang^†, Chun Yuan^‡, Fei Liu^‡, Gador Canton^‡, Jie Zheng^§, Pamela K. Woodard^§, Gregorio A. Sicard^¶, Dalin Tang^||

Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 121-134, 2009, DOI:10.3970/mcb.2009.006.121

Abstract Image-based computational models for atherosclerotic plaques have been developed to perform mechanical analysis to quantify critical flow and stress/strain conditions related to plaque rupture which often leads directly to heart attack or stroke. An important modeling issue is how to determine zero stress state from in vivo plaque geometries. This paper presents a method to quantify human carotid artery axial and inner circumferential shrinkages by using patient-specific ex vivo and in vivo MRI images. A shrink-stretch process based on patient-specific in vivo plaque morphology and shrinkage data was introduced to shrink the in vivo geometry first to find the zero-stress… More >

Chun Yang^1,2, Dalin Tang², Satya Atluri³

CMES-Computer Modeling in Engineering & Sciences, Vol.72, No.1, pp. 53-78, 2011, DOI:10.3970/cmes.2011.072.053

Abstract Previously, we introduced a computational procedure based on three-dimensional meshless generalized finite difference (MGFD) method and serial magnetic resonance imaging (MRI) data to quantify patient-specific carotid atherosclerotic plaque growth functions and simulate plaque progression. Structure-only models were used in our previous report. In this paper, fluid-stricture interaction (FSI) was added to improve on prediction accuracy. One participating patient was scanned three times (T1, T2, and T3, at intervals of about 18 months) to obtain plaque progression data. Blood flow was assumed to laminar, Newtonian, viscous and incompressible. The Navier-Stokes equations with arbitrary Lagrangian-Eulerian (ALE) formulation were used as the governing… More >