Domenico Sirico¹, Biagio Castaldi^1,*, Giuseppe Tarantini², Giovanni Di Salvo¹

Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863

Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically induced hyperemia. Thus, the patient… More >

Long Yu¹, Kesong Xu¹, Jun Wan², Haiyan Lu^3,*, Shengzhang Wang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 835-844, 2019, DOI:10.32604/cmes.2019.07428

Abstract Fractional flow reserve (FFR) computed from computed tomography angiography (CTA), i.e., FFR_CT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery stenosis. It has also been suggested to be used in the assessment of carotid artery stenosis. The wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid stenosis. This work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFR_CT in carotid stenosis. Models of carotid stenosis are established based on CTA image data using computer-aided design software. It is assumed… More >

Aike Qiao^1,*, Honghui Zhang¹, Jun Xia¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 35-35, 2019, DOI:10.32604/mcb.2019.05715

Abstract In order to improve the calculation accuracy of computed tomography angiography-derived fractional flow reserve (FFR_CT), a mathematical model for setting the patient-specific flow boundary condition was proposed, in which some independent physiological parameters, such as myocardial mass, diastolic blood pressure, heart rate and vessel volume were considered. This model was employed to simulate hemodynamics in sixteen patients with coronary stenosis. The results of FFR_CT demonstrated good consistency with invasively measured FFR. The diagnostic accuracy of FFR_CT was 85%. The proposed model offers a new approach to improve the accuracy of FFR_CT, as well as promotes the clinical application of FFR_CT. More >

Yue Feng¹, Youjun Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 31-32, 2019, DOI:10.32604/mcb.2019.05713

Abstract Coronary atherosclerotic heart disease, or coronary heart disease for short, is a heart disease caused by atherosclerotic lesions of coronary arteries, resulting in stenosis, spasm and live obstruction, leading to myocardial ischemia, hypoxia and even necrosis, and is the most common type of organ lesions caused by atherosclerosis. Coronary computed tomograph angiography (CCTA) has been the most effective method for examining coronary heart disease, but this method can only be judged from the morphology. It has been shown that when the coronary stenosis rate is as high as 70%, only 32% of blood vessels can cause myocardial ischemia. Therefore, there… More >

Wenxin Wang^1,2, Dalin Tang², Boyan Mao¹, Bao Li¹, Xi Zhao³, Jian Liu⁴, Youjun Liu^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI: 10.31614/cmes.2018.04219

Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was performed by coupling the 3D… More >