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  • Open Access


    FFR-Guided PCI in a 17-Year-Old Patient after Arterial Switch Operation for D-Transposition of the Great Arteries

    Domenico Sirico1, Biagio Castaldi1,*, Giuseppe Tarantini2, Giovanni Di Salvo1

    Congenital Heart Disease, Vol.15, No.6, pp. 441-445, 2020, DOI:10.32604/CHD.2020.012863

    Abstract Asymptomatic coronary artery obstruction represents a significant diagnostic challenge in patients with Dextro-Transposition of the Great Arteries and history of Arterial Switch Operation. We report the case of a 17-year-old boy with anomalous origin of left circumflex artery from the right coronary artery, who underwent neonatal arterial switch operation and developed silent myocardial ischemia under stress on myocardial scintigraphy. Despite coronary angiogram and intravascular ultrasound showed only intermediate stenosis of the right coronary artery ostium, the physiological analysis, through the employment of pressure wire, demonstrated a severe reduction of coronary fractional flow reserve after pharmacologically induced hyperemia. Thus, the patient… More >

  • Open Access


    Effect of the Wall Thickness of the Vessel on FFRCT of Carotid Artery Stenosis

    Long Yu1, Kesong Xu1, Jun Wan2, Haiyan Lu3,*, Shengzhang Wang1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 835-844, 2019, DOI:10.32604/cmes.2019.07428

    Abstract Fractional flow reserve (FFR) computed from computed tomography angiography (CTA), i.e., FFRCT has been used in the clinic as a noninvasive parameter for functional assessment of coronary artery stenosis. It has also been suggested to be used in the assessment of carotid artery stenosis. The wall thickness of the vessel is an important parameter when establishing a fluid-structure coupling model of carotid stenosis. This work studies the effect of the vessel wall thickness on hemodynamic parameters such as FFRCT in carotid stenosis. Models of carotid stenosis are established based on CTA image data using computer-aided design software. It is assumed… More >

  • Open Access


    Approach to the Flow Rate Distribution of Coronary Branches in the Calculation of Fractional Flow Reserve

    Aike Qiao1,*, Honghui Zhang1, Jun Xia1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 35-35, 2019, DOI:10.32604/mcb.2019.05715

    Abstract In order to improve the calculation accuracy of computed tomography angiography-derived fractional flow reserve (FFRCT), a mathematical model for setting the patient-specific flow boundary condition was proposed, in which some independent physiological parameters, such as myocardial mass, diastolic blood pressure, heart rate and vessel volume were considered. This model was employed to simulate hemodynamics in sixteen patients with coronary stenosis. The results of FFRCT demonstrated good consistency with invasively measured FFR. The diagnostic accuracy of FFRCT was 85%. The proposed model offers a new approach to improve the accuracy of FFRCT, as well as promotes the clinical application of FFRCT. More >

  • Open Access


    Study on the Influence of Right Atrial Pressure on the Numerical Calculation of Fractional Flow Reserve

    Yue Feng1, Youjun Liu1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 31-32, 2019, DOI:10.32604/mcb.2019.05713

    Abstract Coronary atherosclerotic heart disease, or coronary heart disease for short, is a heart disease caused by atherosclerotic lesions of coronary arteries, resulting in stenosis, spasm and live obstruction, leading to myocardial ischemia, hypoxia and even necrosis, and is the most common type of organ lesions caused by atherosclerosis. Coronary computed tomograph angiography (CCTA) has been the most effective method for examining coronary heart disease, but this method can only be judged from the morphology. It has been shown that when the coronary stenosis rate is as high as 70%, only 32% of blood vessels can cause myocardial ischemia. Therefore, there… More >

  • Open Access


    A Fast-Fractional Flow Reserve Simulation Method in A Patient with Coronary Stenosis Based on Resistance Boundary Conditions

    Wenxin Wang1,2, Dalin Tang2, Boyan Mao1, Bao Li1, Xi Zhao3, Jian Liu4, Youjun Liu1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI: 10.31614/cmes.2018.04219

    Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was performed by coupling the 3D… More >

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