ELEONIDAS MOURA LIMA1,2, MARIANA FERREIRA LEAL3, MARÍLIA DE ARRUDA CARDOSO SMITH3, ROMMEL RODRÍGUEZ BURBANO4, PAULO PIMENTEL DE ASSUMPÇÃO5, MARIA JOSE BELLO6, JUAN ANTONIO REY6, FRANCINALDO FERREIRA DE LIMA7, CACILDA CASARTELLI2
BIOCELL, Vol.32, No.3, pp. 237-243, 2008, DOI:10.32604/biocell.2008.32.237
Abstract Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation status of MLH1, MSH2, MSH6 and PMS2 in 20 diffuse- and 26 intestinal-type gastric cancer samples and 20 normal gastric mucosal of gastric cancer patients from Northern Brazil. We found that none of the nonneoplastic samples showed methylation of any gene promoter and 50% of gastric cancer samples showed at least one methylated gene promoter. Methylation frequencies of MLH1, MSH2, MSH6 and PMS2 promoter were 21.74%, 17.39%, 0% and 28.26% respectively in gastric… More >
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