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  • Open Access


    Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

    Ji-Yang Zuo1,2, Huan-Xin Chen1,2, Zhi-Gang Liu1,2, Qin Yang1,2, Guo-Wei He1,2,*

    Congenital Heart Disease, Vol.18, No.1, pp. 7-21, 2023, DOI:10.32604/chd.2022.025451

    Abstract Background: Atrial septal defect (ASD) is one of the common congenital heart diseases. The MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been explored. Methods: In 613 subjects including 320 ASD patients, we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics analysis. Results: Eleven variants were identified in the MYH6 gene promoter, of which four variants were found only in ASD patients, and two variants (g.3434G>C and g.4524C>T) were identified for the first time.… More > Graphic Abstract

    Genetic Analysis of Variants of the <i>MYH6</i> Gene Promoter in Congenital Atrial Septal Defects

  • Open Access


    Morphological and Phylogenetic Resolution of Diplodia neojuniperi Emerging Diplodia Top Dieback of Pinus thunbergii Parl. in China

    Xiaolei Ding, Ruiwen Zhao, Sixi Lin, Jianren Ye*

    Phyton-International Journal of Experimental Botany, Vol.91, No.12, pp. 2813-2825, 2022, DOI:10.32604/phyton.2022.024609

    Abstract In Bazhong City, Sichuan Province, China, top dieback symptoms were found on many pine trees (Pinus thunbergii Parl). The tips of old needles first turned grayish-green and then developed into brown bands in the field. Phylogenetic analysis of concatenated ITS and EF1-α indicated the pathogen of this dieback disease as Diplodia neojuniperi. Additionally, effects of temperature, pH and medium on the mycelial growth were also characterized. The most favorable temperature and pH level for mycelial growth are 25°C and 8, respectively. The optimal medium for mycelial growth is PDA medium. To our knowledge, this is the first report of D.… More >

  • Open Access


    An Optimized Technique for RNA Prediction Based on Neural Network

    Ahmad Ali AlZubi*, Jazem Mutared Alanazi

    Intelligent Automation & Soft Computing, Vol.35, No.3, pp. 3599-3611, 2023, DOI:10.32604/iasc.2023.027913

    Abstract Pathway reconstruction, which remains a primary goal for many investigations, requires accurate inference of gene interactions and causality. Non-coding RNA (ncRNA) is studied because it has a significant regulatory role in many plant and animal life activities, but interacting micro-RNA (miRNA) and long non-coding RNA (lncRNA) are more important. Their interactions not only aid in the in-depth research of genes’ biological roles, but also bring new ideas for illness detection and therapy, as well as plant genetic breeding. Biological investigations and classical machine learning methods are now used to predict miRNA-lncRNA interactions. Because biological identification is expensive and time-consuming, machine… More >

  • Open Access


    Multi-Environmental Genetic Analysis of Grain Size Traits Based on Chromosome Segment Substitution Line in Rice (Oryza sativa L.)

    Yujia Leng1,#, Shuilian Wang1,2,3,#, Ruoan Wang2,#, Tao Tao1, Shuwen Jia1,2, Tao Song2,3, Lina Xu1,2, Xiuling Cai1,2, Sukui Jin1,2,*, Jiping Gao1,2,4,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 943-958, 2022, DOI:10.32604/phyton.2022.018707

    Abstract Grain size traits are critical agronomic traits which directly determine grain yield, but the genetic bases of these traits are still not well understood. In this study, a total of 154 chromosome segment substitution lines (CSSLs) population derived from a cross between a japonica variety Koshihikari and an indica variety Nona Bokra was used to investigate grain length (GL), grain width (GW), length-width ratio (LWR), grain perimeter (GP), grain area (GA), and thousand grain weight (TGW) under four environments. QTL mapping analysis of six grain size traits was performed by QTL IciMapping 4.2 with an inclusive composite interval mapping (ICIM)… More >

  • Open Access


    Phylogenetic analysis and target gene prediction of miR477 gene family in grape


    BIOCELL, Vol.46, No.4, pp. 941-949, 2022, DOI:10.32604/biocell.2022.016718

    Abstract To understand the molecular characteristics of the miR477 gene family of grape (Vvi-miR477) and to predict its target genes, the Vvi-miR477 genes were identified from previous small RNA sequencing data, then phylogenetic analysis and prediction of target gene were conducted. The Vvi-miR477 family consists of two precursor sequences and three mature sequences. The miR477 family members were mostly 19-22nt in length. The sequence is relatively conservative. Vvi-MIR477a and Vvi-MIR477b are located on chromosomes 1 and 2, respectively. These precursor sequences can form the typical stable stem-loop structure. Their minimum folding free energy is −39.10 kcal/mol and −50.90 kcal/mol, respectively. The… More >

  • Open Access


    Complete genome sequence of two strawberry vein banding virus isolates from China


    BIOCELL, Vol.45, No.6, pp. 1695-1702, 2021, DOI:10.32604/biocell.2021.015250

    Abstract It was rarely reported about strawberry vein banding virus (SVBV) genome sequence in China and most countries worldwide. In this work, we determined the complete genome sequences of two SVBV isolates in China, designated SVBV-AH and SVBV-BJ, that were obtained from naturally infected strawberry samples from Anhui province and Beijing city of China, respectively. The complete genomes of SVBV-AH and SVBV-BJ were 7,862 nucleotides (nts) and 7,863 nts long, respectively, and both constituted with seven genes typical of the caulimoviruses. Alignment of complete nucleotide sequences showed that SVBV-AH and SVBV-BJ shared a significant nucleotide sequence identity of 97.7% of each… More >

  • Open Access


    Phylogenetic analysis of microRNA biomarkers for amyotrophic lateral sclerosis


    BIOCELL, Vol.45, No.3, pp. 547-561, 2021, DOI:10.32604/biocell.2021.014343

    Abstract Amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease, is an irreversible disease that is caused by the degeneration and death of motor neurons. Approximately 5–10% of cases are familial ALS (fALS), and the other cases are sporadic ALS (sALS). Gene mutations have been identified both in fALS and sALS patients. In this study, we discuss the four ALS-related genes, C9orf72, SOD1, FUS, and TARDBP, and review the microRNAs (miRNAs) that are associated with ALS and other neurological disorders from the literature. A phylogenetic analysis is used to explore potential miRNAs that can be taken into account when studying the… More >

  • Open Access


    Character Identification of an Early Flowering Mutant

    Zhenzhong Jiang1, Peng Jiao1, Zhuo Qi1, He Zhao2, Jing Qu2, Siyan Liu1, Dan Yao1, Piwu Wang2, Shuyan Guan1,*, Yiyong Ma2,*

    Phyton-International Journal of Experimental Botany, Vol.90, No.2, pp. 449-459, 2021, DOI:10.32604/phyton.2021.013247

    Abstract The concept of gene-function-genetic trait was introduced to explore the effects of early flowering on the growth and development of maize at the jointing stage and to obtain early flowering mutants using ethyl methanesulfonate mutagenesis. First, we studied gene expression, phytohormones, and lignin content to explore the physiological peculiarities of the early flowering mutant. Then we analyzed the genetic features of the mutants during the jointing stage by measuring physiological and biochemical indices of drought tolerance. The results showed that the photosynthetic rate of the mutant was significantly higher than that of the control and the rate of accumulation of… More >

  • Open Access


    Comparative Analyses and Phylogenetic Relationships between Cryptomeria fortunei and Related Species Based on Complete Chloroplast Genomes

    Yingting Zhang1,2,3, Junjie Yang1,2,3, Zhenhao Guo1,2,3, Jiaxing Mo1,2,3, Jiebing Cui1,2,3, Hailiang Hu1,2,3, Jin Xu1,2,3,*

    Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 957-986, 2020, DOI:10.32604/phyton.2020.011211

    Abstract Cryptomeria fortunei (Chinese cedar) is a highly adaptable woody species and one of the main forest plantation trees in subtropical high-altitude areas in China. However, there are few studies on its chloroplast (cp) genome. In this study, the complete cp genome of C. fortunei was sequenced and evaluated via comparative analyses with those of related species (formerly the Taxodiaceae) in Cupressaceae. The C. fortunei cp genome was 131,580 bp in length, and the GC content of the whole genome was 35.38%. It lost one relevant large inverted repeat and contained 114 unique genes, including 82 protein-coding genes, 28 tRNAs and… More >

  • Open Access


    Identification and Genetic Analysis of a Novel Allelic Variation of Brittle-1 with Endosperm Mutant in Maize

    Sen Wang1, Fei Zheng1, Meijing Zhang1, Jun Tu2, Yanping Chen1,3, Jianhua Yuan1,3, Qingchang Meng1,*

    Phyton-International Journal of Experimental Botany, Vol.89, No.4, pp. 861-871, 2020, DOI:10.32604/phyton.2020.011762

    Abstract Endosperm mutants are critical to the studies on both starch synthesis and metabolism and genetic improvement of starch quality in maize. In the present study, a novel maize endosperm mutant A0178 of natural variation was used as the experimental material and identified and then characterized. Through phenotypic identification, genetic analysis, main ingredients measurement and embryo rescue, development of genetic mapping population from A0178, the endosperm mutant gene was located. The results showed that the mutant exhibited extremely low germination ability as attributed to the inhibited embryo development, and amounts of sugars were accumulated in the mutant seeds and more sugars… More >

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