Neslihan Duzkale1,*, Emine Demıral2
Oncologie, Vol.22, No.4, pp. 225-234, 2020, DOI:10.32604/oncologie.2020.014120
Abstract Multiple primary malignant neoplasms (MPMN) are rare tumors that
have attracted attention with increasing incidence rates in recent years and where
cancer susceptibility genes may play a role in their etiology. In this study, it was
aimed to determine the genotype-phenotype correlation in patients with MPMN.
From January 2018 to January 2020, thirty patients were analyzed for 59 cancer
susceptibility genes and diagnosed with MPMN, using a large multigene panel
with Next Generation Sequencing technique (NGS) in Turkey. The mean age of
first and second cancer diagnosis of cases were calculated as 42.5 and 49.9
(respectively). These primary cancers were… More >
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