LEI FU1, JINGWEN JIANG2, XUEWU CHEN2, FENGTING ZHU2, HUI ZHANG2
BIOCELL, Vol.46, No.5, pp. 1289-1297, 2022, DOI:10.32604/biocell.2022.016726
Abstract The levels of hsa circular RNA_0002198 (hsa_circ_0002198) have been found to be significantly upregulated in keloid dermal fibroblasts. However, the functional role of hsa_circ_0002198 in keloid fibroblasts and the underlying molecular mechanism for its effects have not been reported. In this study, the levels of hsa_circ_0002198 and nucleotide-binding and oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) expression in keloid scar tissues and adjacent normal skin tissues were determined by quantitative real-time PCR and western blotting, respectively. In vitro models of keloid tissue were created by culturing primary keloid fibroblasts obtained from patients. A series of functional… More >
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