Shaozhi Zhang, Ruoyi Xie, Mengjie Xu, Guangming Chen*
FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.6, pp. 1177-1189, 2020, DOI:10.32604/fdmp.2020.010352
Abstract Pre-freezing is an important stage in freeze-drying processes. For the
lyophilization of a cell, freezing not only plays a role for primary dehydration,
but it also determines the amount of residual (intracellular or extracellular) water,
which in turn can influence the solution properties and the choice of operation
parameters. The freezing of human platelets in lyoprotectant solution is theoretically investigated here. A two-parameter model and an Arrhenius expression are
used to describe cell membrane permeability and its temperature dependency. It is
assumed that the intracellular solution is composed of four components: sodium
chloride, trehalose, serum protein and water, while the… More >
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