Evan Pagano1, Benjamin Frank1, James Jaggers2, Mark Twite3, Tracy T. Urban4, Jelena Klawitter2,#, Jesse Davidson1,#,*
Congenital Heart Disease, Vol.15, No.4, pp. 251-265, 2020, DOI:10.32604/CHD.2020.012219
Abstract Objectives: (1) To measure the global shift in the metabolome in
hypoxemic versus non-hypoxemic infants with congenital heart disease; (2) To
identify metabolites and metabolic pathways that are altered in hypoxemia. Study
Design: Analysis of serum samples obtained prior to cardiopulmonary bypass
from 82 infants ≤120 days old with congenital heart disease requiring surgery
at Children’s Hospital Colorado. Infants were divided into groups based on preoperative oxygen saturations: non-hypoxemic (>92%), mild hypoxemia
(85–92%), and severe hypoxemia (<85%). Tandem mass spectrometry was used
to analyze 165 targeted metabolites. Partial least squares discriminant analysis and
t-tests were used to determine differences among… More >
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