MI HEON RYU1,a, JEONG HEE PARK1,a, JI EUN PARK1, JIN CHUNG2, CHANG HUN LEE3AND HAE RYOUN PARK1*
BIOCELL, Vol.34, No.1, pp. 15-22, 2010, DOI:10.32604/biocell.2010.34.015
Abstract Tumor cells are often found under hypoxic conditions due to the rapid outgrowth of their vascular supply, and, in order to survive hypoxia, these cells induce numerous signaling factors. Akt is an important kinase in cell survival, and its activity is regulated by the upstream phosphoinositide 3-kinase (PI3K) and receptor tyrosine kinases (RTKs). In this study, we examined Akt activation and RTKs/PI3K/Akt signaling using the hypoxia-mimetic cobalt chloride in oral squamous carcinoma cells. Cobalt chloride increases Akt phosphorylation in both a dose- and time-dependent manner. Blocking the activation of the PI3K/Akt pathway using LY294002 abolished Akt activation in response to… More >
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