Raghav Mishra1,2,*, Nitin Kumar3, Neetu Sachan2
Oncologie, Vol.23, No.4, pp. 493-514, 2021, DOI:10.32604/oncologie.2021.018532
Abstract The relevance of Retinoic acid receptor-related orphan receptors in cancer progression has sparked interest in
developing multifunctional therapeutics. In the search for potentially active novel compounds with anticancer
characteristics, the Gewald reaction was employed to develop different thiophene derivatives (8a–8i). Physicochemical and spectroanalytical investigations verified the molecular structures of the synthesized derivatives.
Using an in vitro primary anticancer assay, NCI chose all of the synthesized molecules as prototypes and assessed
their anticancer efficacy against a panel of various cancer cell lines representing nine distinct neoplasms. The
compounds were found to have a wide range of anticancer activity. Following significant anticancer… More >
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