Yanhong ZHEN1, Li HAN2, Kailai CAI1, Lijun HUO1, Hasan RIAZ1, Canjie WU1, Aixin LIANG1 , Lei SANG1, Liguo YANG1 *
BIOCELL, Vol.38, No.1, pp. 17-24, 2014, DOI:10.32604/biocell.2014.38.017
Abstract Inhibins play important roles in the reproductive system. To evaluate whether inhibin α (1-32)
fusion protein plays a role in cervical cancer growth, the plasmid pVAX-inhα was constructed and its effect on
proliferation and apoptosis of the human cervical cancer cell line (Hela) was checked by flow cytometry and
real-time PCR. The expression and localization of inhibin α protein were detected by RT-PCR and confocal microscopy which showed that inhibin α protein was expressed and localized in the nucleus of Hela cells. Over expression of inhibin α gene significantly induced cell apoptosis and ceased S phase of cell cycle. Furthermore,… More >
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