So-Ye Jeon^1,#, Zeeshan Ahmad Bhutta^1,#, Hong Kyu Lee², Kyung-Chul Choi^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.071328 - 23 March 2026

Abstract Objectives: Progesterone (P4) is believed to inhibit breast cancer growth, but its role in counteracting estrogen (E2)-driven progression remains unclear. This study aimed to investigate the inhibitory effect of P4 on E2-induced cell proliferation, migration, and invasion in Estrogen receptor (ER)+/progesterone receptor (PR)+ breast cancer cells by examining its regulatory role in the epithelial-mesenchymal transition (EMT). Methods: ER and PR-positive MCF-7 clonal variant (MCF-7 CV) breast cancer cells were treated with E2 and co-treated with various concentrations of P4. The effects on cell proliferation, migration, and invasion were assessed. The expression of key EMT markers… More >

Shaimaa R. Ahmed^1,*, Omnia M. Hendawy², Sumera Qasim², Hanan Khojah³, Ambreen Malik Uttra⁴

Phyton-International Journal of Experimental Botany, Vol.95, No.2, 2026, DOI:10.32604/phyton.2026.075718 - 28 February 2026

Abstract The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract (ASE) by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase (MMP), collagenase, elastase, hyaluronidase, and tyrosinase in relation to its chemical composition. Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) identified 27 metabolites (15 flavonoids, 8 phenolic acids and their derivatives, and 4 coumarins). ASE showed strong antioxidant capacity in DPPH (IC₅₀ value of 26.05 µg/mL) and FRAP (2433 µM FeSO₄/g extract) assays. The extract inhibited MMP-1 and MMP-9 in a concentration-dependent manner and suppressed collagenase, elastase, hyaluronidase, and tyrosinase activities (IC₅₀ = 35.038, 40.748, 61.389,… More > Graphic Abstract

Manar Bouhchich¹, Abdessadek Rahimi¹, Rhizlan Abdnim², Amine Elbouzidi^3,*, Mohamed Addi³, Mostafa Mimouni¹

Phyton-International Journal of Experimental Botany, Vol.95, No.2, 2026, DOI:10.32604/phyton.2026.074293 - 28 February 2026

Abstract Date palm (Phoenix dactylifera L.) seeds, often discarded as by-products during date fruit processing, represent approximately 6–20% of the fruit’s mass depending on cultivar and maturity stage. Although traditionally used for producing activated charcoal and in environmental remediation, their pharmacological potential remains underexplored. This study aimed to evaluate the chemical composition, biological activity, and potential commercial value of seeds from four widely consumed Saharan cultivars (Assiane, Boufegouss, Aziza, and Majhoul) collected in the Figuig region. Soxhlet extraction was employed to obtain seed extracts, which were subsequently characterized by qualitative and quantitative phytochemical screening. The analyses revealed… More >

Heba A. S. El-Nashar^1,*, Ahmed T. Negmeldin^2,3,*, Aziza El Baz⁴, Marizé Cuyler⁵, Brandon Alston⁵, Namrita Lall^5,6,7, Naglaa S. Ashmawy^1,8,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3269-3281, 2025, DOI:10.32604/phyton.2025.067998 - 29 October 2025

Abstract Pimenta dioica is a tropical Caribbean tree belonging to the family Myrtaceae, widely used in various human activities, including perfume production, food flavoring, natural pesticides, and medicine. This study aimed to explore the chemical composition of Pimenta dioica flower essential oil obtained via hydrodistillation using GC-MS analysis. Additionally, the oil’s tyrosinase inhibitory activity was investigated. The effectiveness of the oil’s major constituents in binding to tyrosinase was also evaluated through molecular docking simulations. GC-MS analysis identified fifteen compounds, with eugenol (70.59%) as the major component, followed by β-myrcene (10.54%), limonene (8.55%), β-ocimene (4.92%), α-phellandrene (1.39%), and linalool… More >

Junqi Guo^1,2, Yun Yang^1,2, Wei Zhao^1,2, Zhonghai Yan³, Xia Yang⁴, Yunfei Yan^1,2, Ruimin Hao^1,2, Jinxia Hu^1,2,*, Fei Jiao^1,2,*

BIOCELL, Vol.49, No.9, pp. 1797-1797, 2025, DOI:10.32604/biocell.2025.071013 - 25 September 2025

Abstract This article has no abstract. More >

Yun Wang^1,2,#, Xin-Yu Li^1,3,#, Sheng-Li Wu^1,3, Pianchou Gongpan¹, Da-Hong Li², Chang-An Geng^1,3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2563-2574, 2025, DOI:10.32604/phyton.2025.068185 - 29 August 2025

Abstract Twelve lignans (1–12) isolated from Amomum tsao-ko leaves were evaluated for the inhibitory effects against α-glucosidase and PTP1B. Compounds 1−4 and 10 showed inhibition on α-glucosidase with inhibitory ratios ranging from 53.8% to 90.0%, while compound 10 demonstrated 56.1% inhibition on PTP1B at 200 μM. Notably, erythro-5-methoxy-dadahol A (2) and threo-5-methoxy-dadahol A (3) displayed obvious inhibition on α-glucosidase with IC₅₀ values of 33.3 μM and 22.1 μM, significantly outperforming acarbose (IC₅₀ = 344.0 μM). Kinetic study revealed that compound 3 maintained a mixed-type mode, engaging with both free enzyme and enzyme-substrate complex via non-competitive and uncompetitive mechanisms. Molecular docking simulations further clarified its More >

Ahmed Mahmoud Ismail^1,2,3,*, Eman Said Elshewy³, Isra H. Ali^4,5, Naglaa Abd Elbaki Sallam Muhanna³, Eman Yehia Khafagi³

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 2787-2811, 2024, DOI:10.32604/phyton.2024.057518 - 30 November 2024

Abstract Rhizoctonia solani Kühn and Sclerotium rolfsii Sacc. are the primary soil-borne plant diseases responsible for significant reductions in global crop yields. The primary goal of this study was to investigate the antifungal potentials of clove essential oil (CEO), nanoemulsion form (CEONE) and chitosan/nanoemulsion nanocomposite (CS/CEONE) against R. solani and S. rolfsii through in vitro and in vivo trials. Both CEONE and CS/CEONE were prepared and investigated for their physical chemical and morphological characterization. The poisoned medium method was utilized to evaluate the inhibitory effects of CEO, CEONE and CS/CEONE on the mycelial growth and enzymatic activity of R. solani and S. rolfsii. The… More >

Lili Liu¹, Can Hu⁴, Huilin Cheng¹, Chuangju Ma¹, Jiancheng Sun¹, Yunyi Chen², Manxi Wu², Han Yang², Cui Sun^2,3, Jinping Cao^2,3, Dengliang Wang^1,*, Yue Wang^2,*, Chongde Sun^2,3

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2499-2518, 2024, DOI:10.32604/phyton.2024.054449 - 30 September 2024

Abstract Oral ulcers, a common mucosal affliction, severely diminish patients’ quality of life due to pain and discomfort. Despite existing treatments, the frequent recurrence of oral ulcers underscores the need for more effective therapeutic options. This study aimed to investigate the inhibitory effects of Ponkan (Citrus reticulata ‘Ponkan’) extracts and their flavonoid components on oral ulcers, exploring their potential as a natural therapy. Twenty different Ponkan cultivars were selected for flavonoid extraction and analysis. Ultra-performance liquid chromatography (UPLC) and high-resolution mass spectrometry (HRMS) were utilized for substance identification, leading to the discovery of 16 flavonoid compounds. Using… More > Graphic Abstract

Xiaolu Qin^1,3, Xinyu Li^1,3, Yi Yang², Mei Huang², Shengli Wu¹, Pianchou Gongpan¹, Lianzhang Wu², Juncai He², Changan Geng^1,3,*

Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 875-883, 2024, DOI:10.32604/phyton.2024.048192 - 28 May 2024

Abstract The fruits of Amomum tsao-ko (Cao-Guo) were documented in Chinese Pharmacopoeia for the treatment of abdominal pain, vomiting, and plague. In our previous study, a series of diarylheptanes and flavonoids with α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity have been reported from the middle-polarity part of A. tsao-ko, whereas the antidiabetic potency of the low-polarity constituents is still unclear. In this study, three new hydroxytetradecenals, (2E, 4E, 8Z, 11Z)-6R-hydroxytetradeca-2,4,8,11-tetraenal (1), (2E, 4E, 8Z)-6R-hydroxytetradeca-2,4,8-trienal (2) and (2E, 4E)-6R-hydroxytetradeca-2,4-dienal (3) were obtained from the volatile oils of A. tsao-ko. The structures of compounds 1–3 were determined using spectroscopic data involving 1D and 2D nuclear magnetic More >

NAN TANG^1,#, YAJING ZHAN^1,#, JIAYAN MAO^2,#, ANKANG YIN¹, WEI WANG^3,*, JUAN WANG^3,*

BIOCELL, Vol.47, No.9, pp. 2009-2026, 2023, DOI:10.32604/biocell.2023.029269 - 28 September 2023

Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. Triptolide (TP), extracted from Tripterygium wilfordii Hook F, exhibits potent broad-spectrum antitumor activity. Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. In this study, the transcriptome and proteome were integrated and analyzed. Our data indicated ribosomal protein L4 (RPL4) to be a core hub protein in the protein-protein interaction network. RPL4 is overexpressed in NSCLC tissues and cells. Transfection with siRPL4 or TP treatment alone arrested the cell cycle in More > Graphic Abstract