Qi Li^1,2, Ningli Wang³, Zhicheng Liu^1,2, Lin Li^1,2, Zhicheng Liu^1,2, Wenjia Wang^1,2, Xiaoxue Long^1,2, Hongfang Song^1,2,*

Molecular & Cellular Biomechanics, Vol.17, No.3, pp. 119-137, 2020, DOI:10.32604/mcb.2020.09529

Abstract Aim: To investigate the relationship between glaucoma and intraocular pressure (IOP), intracranial pressure (ICP), trans-laminar cribrosa pressure difference (TLCPD), and the newly proposed fractional pressure reserve (FPR). Methods: Ten articles were analyzed by meta-analysis, and subgroup analysis of three factors was conducted. Results: The patients with normal tension glaucoma (NTG) and open-angle glaucoma (OAG) have higher TLCPD and lower ICP than healthy subjects, with obvious heterogeneity. The greater heterogeneity may arise from different ICP measurements and from different countries or regions. FPR performs better than TLCPD in some ways. Conclusion: Both FPR and TLCPD can be used as indicators of… More >

Xiuqing Qian^1,2, Fan yuan^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 89-89, 2019, DOI:10.32604/mcb.2019.07041

Abstract Elevated intraocular pressure (IOP) is the most important risk factor for disease progression in glaucoma patients. The elevation is predominantly due to the increase in the aqueous outflow resistance in the trabecular outflow pathway. Recent data have shown that the resistance increase is correlated with changes in the tissue stiffness. To this end, we developed a mathematical model to simulate how the tissue stiffness can affect the deformation of the trabecular meshwork (TM) that can be determined experimentally. The goal of the study is to develop a method to non-invasively determine the TM stiffness in patients through measurement of the… More >

Mahesh B. Mawale^1,*, Abhaykumar Kuthe², Dr. Padma Pawane³, Sandeep W. Dahake², Jyotilal S²

Molecular & Cellular Biomechanics, Vol.13, No.2, pp. 105-114, 2016, DOI:10.3970/mcb.2016.013.119

Abstract Purpose: The main purpose of this study is to develop a device for the indicative measurement of intraocular pressure (IOP) of eyeball, a key cause for glaucoma. In early diagnosis and treatment of glaucoma accurate measurement of IOP is important. The methods and devices which are available for the measurement of IOP have their own limitations which cause discomfort to the patients during measurement and needs anesthesia. There is a dare need of a device for the measurement of intraocular pressure by making the contact of plunger with closed eyelid eliminating the need of anesthesia and expert ophthalmologist. Method: Additive… More >

Match W L Ko^∗, Leo K K Leung^∗, David C C Lam^∗,†

Molecular & Cellular Biomechanics, Vol.9, No.4, pp. 251-268, 2012, DOI:10.3970/mcb.2012.009.251

Abstract Inter-individual differences in corneal properties are ignored in existing methods for measuring intraocular pressure IOP, a primary parameter used in screening and monitoring of glaucoma. The differences in the corneal stiffness between individuals can be more than double and this difference would lead to IOP measurement errors up to 10 mmHg. In this study, an instrumented partial-contact indentation measurement and analysis method that can account for inter-individual corneal difference in stiffness is developed. The method was tested on 12 porcine eyes ex vivo and 7 rabbit eyes in vivo, and the results were compared to the controlled IOPs to determine… More >

Leo KK Leung^∗, Match WL Ko^∗, David CC Lam^†

Molecular & Cellular Biomechanics, Vol.9, No.2, pp. 157-174, 2012, DOI:10.3970/mcb.2012.009.157

Abstract Age-stiffening of ocular tissues is statistically linked to glaucoma in the elderly. In this study, the effects of age-stiffening on the lamina cribrosa, the primary site of glaucomatous nerve damages, were modeled using computational finite element analysis. We showed that glaucomatous nerve damages and peripheral vision loss behavior can be phenomenologically modeled by shear-based damage criterion. Using this damage criterion, the potential vision loss for 30 years old with mild hypertension of 25mmHg intraocular pressure (IOP) was estimated to be 4%. When the IOP was elevated to 35mmHg, the potential vision loss rose to 45%; and age-stiffening from 35 to… More >

Arthur J. Sit^*, John H.K. Liu^†

Molecular & Cellular Biomechanics, Vol.6, No.1, pp. 57-70, 2009, DOI:10.3970/mcb.2009.006.057

Abstract Glaucoma is a leading cause of visual impairment and blindness worldwide. The main risk factor for glaucoma is an elevated intraocular pressure (IOP), which is also the only currently treatable risk factor. Despite its importance, our understanding of IOP is incomplete and our ability to measure IOP is limited. IOP is known to undergo both random fluctuations as well as variations following a circadian pattern. In humans, IOP is highest at night and lower during the daytime, largely due to changes in body position, although other factors appear to contribute. In rabbits, IOP is also highest at night and lower… More >

Mahesh B. Mawale¹, Abhaykumar Kuthe², Padma G. Pawane³, Sandeep W. Dahake²

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.2, pp. 173-189, 2018, DOI:10.3970/cmes.2018.114.173

Abstract This article describes a study based on the use of an instrumented form of applanation and indentation tonometry through eyelid. The methods and devices which are available for the measurement of intraocular pressure (IOP) have their own limitations. These cause discomfort to the patients during IOP measurement. Also these methods, used to measure IOP over cornea, need anesthesia. In the present work, an attempt is made to develop a device for the measurement of IOP through eyelid which eliminates the need of anesthesia and enhance the patient’s comfort and convenience of the clinician. To represent the results of proposed technique,… More >