MIN SHEN^1,2, XIAOMAN XU^1,2, GUANGLING SUN¹, LIANGZHU WANG¹, TAO YING¹, HANG SU¹, WEI WANG¹, QINGHUA CAO^1,*, ZHEZHE SUN^1,*

BIOCELL, Vol.48, No.3, pp. 491-499, 2024, DOI:10.32604/biocell.2023.047640

Abstract Objective: Circular RNAs (circRNAs) have been shown to involve in pathological processes of ischemic stroke (IS), including autophagy. This study was designed to explore the effect of circR-ZC3HC1 on neuronal autophagy in IS and the related mechanisms. Methods: Expression of circR-ZC3HC1 in blood samples of IS patients and healthy controls was detected. Hippocampal neurons were treated with oxygen and glucose deprivation (OGD) to establish IS in vitro model. The expression of LC3 and p62 and the number of autophagosomes were examined to evaluate the autophagy level of OGD induced neurons using western blotting and transmission electron microscope. Cell apoptosis rate… More >

LUOJUN ZHENG, LUAN WENG, DIWEN SHOU^*

BIOCELL, Vol.47, No.6, pp. 1345-1352, 2023, DOI:10.32604/biocell.2023.028866

Abstract Background: Ischemic stroke is characterized by permanent or transient obstruction of blood flow, leading to a growing risk factor and health burden. Tianmagouteng yin (TMG) is commonly used in Chinese medicine to treat cerebral ischemia. The aim of this study was to investigate the neuroprotective effects of TMG against ischemic stroke. Methods: Either permanent middle cerebral artery occlusion (pMCAO) or sham operation was performed on anesthetized Wistar male rats (n = 36). Results: Results demonstrated that TMG administration reduced the infarction volume and mitigated the neurobehavioral deficits. Hematoxylin and eosin (HE) staining and Prussian blue staining revealed that TMG attenuated… More >

Azhar Tursynova¹, Batyrkhan Omarov^1,2, Natalya Tukenova^3,*, Indira Salgozha⁴, Onergul Khaaval³, Rinat Ramazanov⁵, Bagdat Ospanov⁵

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1431-1446, 2023, DOI:10.32604/cmc.2023.034400

Abstract In the field of stroke imaging, deep learning (DL) has enormous untapped potential. When clinically significant symptoms of a cerebral stroke are detected, it is crucial to make an urgent diagnosis using available imaging techniques such as computed tomography (CT) scans. The purpose of this work is to classify brain CT images as normal, surviving ischemia or cerebral hemorrhage based on the convolutional neural network (CNN) model. In this study, we propose a computer-aided diagnostic system (CAD) for categorizing cerebral strokes using computed tomography images. Horizontal flip data magnification techniques were used to obtain more accurate categorization. Image Data Generator… More >

Shakunthala Masi^*, Helenprabha Kuttiappan

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 733-744, 2023, DOI:10.32604/iasc.2023.025919

Abstract In medical science for envisaging human body’s phenomenal structure a major part has been driven by image processing techniques. Major objective of this work is to detect of cerebral atherosclerosis for image segmentation application. Detection of some abnormal structures in human body has become a difficult task to complete with some simple images. For expounding and distinguishing neural architecture of human brain in an effective manner, MRI (Magnetic Resonance Imaging) is one of the most suitable and significant technique. Here we work on detection of Cerebral Atherosclerosis from MRI images of patients. Cerebral Atherosclerosis is a cerebral vascular disease causes… More >

Batyrkhan Omarov^1,2,3, Azhar Tursynova^1,*, Octavian Postolache⁴, Khaled Gamry⁵, Aidar Batyrbekov⁵, Sapargali Aldeshov^6,7, Zhanar Azhibekova⁹, Marat Nurtas^5,8, Akbayan Aliyeva⁶, Kadrzhan Shiyapov^10,11

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 4701-4717, 2022, DOI:10.32604/cmc.2022.020998

Abstract The task of segmentation of brain regions affected by ischemic stroke is help to tackle important challenges of modern stroke imaging analysis. Unfortunately, at the moment, the models for solving this problem using machine learning methods are far from ideal. In this paper, we consider a modified 3D UNet architecture to improve the quality of stroke segmentation based on 3D computed tomography images. We use the ISLES 2018 (Ischemic Stroke Lesion Segmentation Challenge 2018) open dataset to train and test the proposed model. Interpretation of the obtained results, as well as the ideas for further experiments are included in the… More >

FEI TIAN^*, GANG LIU, LINLIN FAN, ZHONGYUN CHEN, YAN LIANG,

BIOCELL, Vol.45, No.1, pp. 49-56, 2021, DOI:10.32604/biocell.2021.013794

Abstract Cerebral ischemia is due to the formation of blood clots or embolisms in the brain arteries, which leads to local brain tissue necrosis and neural cell apoptosis. Recent studies have shown that microRNA (miRNA) plays an important regulatory role in the pathological process of ischemic injury. The aim of this study is to investigate the role and the mechanism of miR-21-3p and drosophila mothers against decapentaplegic 2 (SMAD2) in cerebral ischemic reperfusion injured (CIRI) neural cells. The CIRI model was established by oxygen-glucose deprivation and recovery process for N2a cells. The cell viability and the apoptotic was evaluated by MTT… More >

Shu Q. Liu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 5-7, 2019, DOI:10.32604/mcb.2019.06960

Abstract This article has no abstract. More >

Shu Q. Liu^*

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 75-85, 2019, DOI:10.32604/mcb.2019.06920

Abstract Ischemic stroke, although causing brain infarction and neurological deficits, can activate innate neuroprotective mechanisms, including regional mechanisms within the ischemic brain and distant mechanisms from non-ischemic organs such as the liver, spleen, and pancreas, supporting neuronal survival, confining brain infarction, and alleviating neurological deficits. Both regional and distant mechanisms are defined as systems neuroprotective mechanisms. The regional neuroprotective mechanisms involve release and activation of neuroprotective factors such as adenosine and bradykinin, inflammatory responses, expression of growth factors such as nerve growth factors and neurotrophins, and activation and differentiation of resident neural stem cells to neurons and glial cells. The distant… More >