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    Differential mRNA expression in peripheral blood is associated with oral squamous cell carcinoma: Recent advances and future challenges

    XIA MU1,2,#, YUBING HU3,#, DANDAN WU1,#, HONGYU YANG1,2,*

    BIOCELL, Vol.47, No.7, pp. 1449-1458, 2023, DOI:10.32604/biocell.2023.026704

    Abstract Oral squamous cell carcinoma (OSCC) is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial cells. Different OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of OSCC. Recent advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood biomarkers. Hence, blood biomarker detection has become an efficient screening tool for the early diagnosis of OSCC. The growing data available in public cancer and gene databases have provided new foundations for OSCC research. In particular, the identification… More >

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