Yao Guo1, Yijiang Song2, Yu Zhang1, Li Yang1,*
Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 119-119, 2019, DOI:10.32604/mcb.2019.07134
Abstract Osteoarthritis (OA), with its high disability and mortality rate, is the most common arthritis throughout the world [1]. Exposure of articular cartilage to excessive mechanical stress is deeply involved in the pathogenesis of osteoarthritis (OA) [2,3]. However, the mechanism of how mechanical stress causes cartilage degradation is not clear yet. Here we report that bioinformatics-based integrative analyses can assist in the study of mechanisms modulated by mechanical stress within OA pathology, and we reveal that B-cell Translocation Gene 2 (BTG2) can be a mechanosensitive gene involved in OA development. We obtained OA-associated differentially expressed genes from human and rat datasets… More >
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