MÓNICA S. OLIVELLA, NORA B. DEBATTISTA, NORA B. PAPPANO
BIOCELL, Vol.30, No.2, pp. 321-324, 2006, DOI:10.32604/biocell.2006.30.321
Abstract Considering the skin´s function, different dermal pharmaceutical forms can be developed according to the type of therapeutic activity, active principle and excipients involved in the formulation, such as “transdermal preparations”. In the present study, the permeation parameters of the non-steroidal antiinflammatory drug, salicylic acid (SA) through synthetic membrane, polyvinyliden difluoride, and a biological membrane, egg shell membrane, with different vehicles, propylene glycol, isopropyl alcohol and carbopol gel, were determined. The reported physicochemical parameters of SA from CG were significantly higher than those obtained using PG and IP. This is attributed to the lipophilic nature of the vehicle that facilitates the… More >
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