KARAN WADHWA¹, PAYAL CHAUHAN¹, SHOBHIT KUMAR², RAKESH PAHWA^3,*, RAVINDER VERMA⁴, RAJAT GOYAL⁵, GOVIND SINGH¹, ARCHANA SHARMA⁶, NEHA RAO³, DEEPAK KAUSHIK^1,*

Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive and systematic search of… More > Graphic Abstract

XIAOXI WANG¹, YANFEI JIA², QIANG LI², QIANG YANG², YINGFENG LIU¹, BEIFENG WEI¹, XIANG NIU¹, YINJIE ZHANG¹, XIAODONG LUO², ZIYU ZHAO^1,*, PENG WANG^1,*

Oncology Research, Vol.32, No.5, pp. 933-941, 2024, DOI:10.32604/or.2023.042581

Abstract MicroRNA (miR)-200b-3p has been associated with many tumors, but its involvement in pituitary adenoma is unclear. This study investigated the molecular mechanism underlying miR-200b-3p regulation in pituitary adenomas to provide a theoretical basis for treatment. Bioinformatics was used to analyze pituitary adenoma-related genes and screen new targets related to RECK and miRNA. As well, the relationship between miR-200b-3p and RECK protein was verified using a double-luciferase reporter gene assay. The expression of miR-200b-3p in clinical samples was analyzed by in situ hybridization. Transfection of the miR-200b-3p inhibitor and small interfering-RECK (si-RECK) was verified by qPCR. GH3 cell viability and proliferation… More >

DIPESHKUMAR D. KACHHADIYA, Z.V.P. MURTHY^*

Journal of Polymer Materials, Vol.38, No.1-2, pp. 49-61, 2021, DOI:10.32381/JPM.2021.38.1-2.5

Abstract The conventional process for methanol-water separation like distillation consumes about 60 % of total energy. As an alternative, researchers have developed a membrane-based separation process for alcohol-water mixtures separation. However, there is a big challenge for researches to separate alcohol-water aqueous mixtures using a polymeric membrane because of swelling. In the present work, the aim is to separate methanol from water by pervaporation using polymeric membranes made up of polyvinylidenefluroide (PVDF) and polyethylene glycol (PEG200) modified PVDF membranes. The membranes were characterized by thermogravimetry analysis (TGA), field emission scanning electron microscopy (FE-SEM), and Fourier-transform infrared spectroscopy (FTIR). A study on… More >

SHIVA ARUN^a, VINAY KUMAR SINGH^a,#, PRABHA BHARTIYA^b, PRADIP KUMAR DUTTA^c,*

Journal of Polymer Materials, Vol.40, No.1-2, pp. 19-31, 2023, DOI:10.32381/JPM.2023.40.1-2.2

Abstract Biocompatible polymer chitosan has note-worthy applications in biomedical science. Nanohybrids synthesized by using chitosan as an encapsulating unit for polyoxometalates (POMs) and study of its biomedical applications is a fast-emerging field. In this research work, a lacunary polyoxometalate (α-K₈SiW₁₁O₃₉) has been synthesized and then alkylsilane has been inserted into its lacunary position. It has been then reacted with 2-hydroxy-1-naphtaldehyde followed by copper metalation and finally encapsulated into chitosan by using the ionotropic gelation technique, in which the chitosan and the POM served as cation and anion, respectively. The bands in UV-Vis spectra at characteristic wavelength indicate that the organosilane is… More >

He Wang^1,*, Ying He²

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 889-899, 2024, DOI:10.32604/fdmp.2023.042728

Abstract Magnetohydrodynamic (MHD) induction pumps are contactless pumps able to withstand harsh environments. The rate of fluid flow through the pump directly affects the efficiency and stability of the device. To explore the influence of induction pump settings on the related delivery speed, in this study, a numerical model for coupled electromagnetic and flow field effects is introduced and used to simulate liquid metal lithium flow in the induction pump. The effects of current intensity, frequency, coil turns and coil winding size on the velocity of the working fluid are analyzed. It is shown that the first three parameters have a… More >

Morteza Eslamian^*

Frontiers in Heat and Mass Transfer, Vol.2, No.4, pp. 1-20, 2011, DOI:10.5098/hmt.v2.4.3001

Abstract Recent advances in thermodiffusion (Soret effect) in binary and higher multicomponent liquid mixtures are reviewed. The mixtures studied include the hydrocarbon, associating, molten metal and semiconductor, polymer, and DNA mixtures. The emphasis is placed on the theoretical works, particularly models based on the nonequilibrium thermodynamics, although other approaches such as the statistical, kinetic and hydrodynamic approaches are discussed as well. For each mixture, the major theoretical and experimental works are discussed and the research trends and challenges are addressed. Some of the challenges include a need for combining various methods to develop a comprehensive theoretical model or at least to… More >

Sina Alavi, Mohammad Passandideh-Fard^*

Frontiers in Heat and Mass Transfer, Vol.2, No.2, pp. 1-9, 2011, DOI:10.5098/hmt.v2.2.3007

Abstract In this paper, a numerical study is performed to investigate the effects of thermal shrinkage on the deposition of molten particles on a substrate in a thermal spray process using the Volume-of-Fluid (VOF) method. Thermal shrinkage is a phenomenon caused by the variation of density during cooling and solidification of a molten metal. The Navier-Stokes equations along with the energy equation including phase change are solved using a 2D/axisymmetric mesh. The VOF method is used to track the free surface of molten particles, and an enthalpy-porosity formulation is used to model solidification. For the normal impact of tin particles in… More >

Jing Huang, Kapil Baheti, J. K. Chen^*, Yuwen Zhang

Frontiers in Heat and Mass Transfer, Vol.2, No.1, pp. 1-10, 2011, DOI:10.5098/hmt.v2.1.3005

Abstract An axisymmetric model for thermal transport in thin metal films irradiated by an ultrashort laser pulse was developed. The superheating phenomena including preheating, melting, vaporization and re-solidification were modeled and analyzed. Together with the energy balance, nucleation dynamics was employed iteratively to track the solid-liquid interface and the gas kinetics law was used iteratively to track the liquid-vapor interface. The numerical results showed that higher laser fluence and shorter pulse width lead to higher interfacial temperature, larger melting and ablation depths. A simplified 1-D model could overestimate temperature response and ablation depth due to the omission of radial heat conduction. More >

Yunpeng Ren, J. K. Chen^*, Yuwen Zhang

Frontiers in Heat and Mass Transfer, Vol.3, No.2, pp. 1-7, 2012, DOI:10.5098/hmt.v3.2.3001

Abstract Heat transfer in a copper film irradiated by a femtosecond (fs) laser pulse train and by an integrated dual laser beam of a nanosecond pulse with a fspulse train was studied using the semi-classical two-temperature model. The critical point model with three Lorentzian terms was employed to characterize transient optical properties for the laser energy deposition. The effects of pulse number and separation time on the thermal response were investigated. The results showed that with the same total energy in a fs-pulse train, more pulses for shorter separation time, e.g., 1 ps, and fewer pulses for longer separation time, e.g.,… More >

PING YANG^1,2,3, YUANXIANG LAN^1,2, ZHONG ZENG^1,2, YAN WANG^1,2, HECHUN XIA^1,2,*

BIOCELL, Vol.48, No.1, pp. 149-162, 2024, DOI:10.32604/biocell.2023.042367

Abstract Background: As a form of biological therapy, placenta-derived mesenchymal stem cells (PDMSCs) exhibit considerable promise in addressing the complex pathological processes of traumaticbrain injury (TBI) due to their multi-target and multi-pathway mode of action. Material & Methods: This study investigates the protective mechanisms and benefits of PDMSCs in mitigating the effects of controlled cortical impact (CCI) in rats and glutamate-induced oxidative stress injury in HT22 cells in vitro. Our primary objective is to provide evidence supporting the clinical application of PDMSCs. Results: In the in vivo arm of our investigation, we observed a swift elevation of matrix metalloproteinase-9 (MMP-9) in… More > Graphic Abstract