Nidia FERRAROTTI1, Rosario MUSACCO-SEBIO2, Christian SAPORITO-MAGRIÑÁ2, Juan Manuel ACOSTA2, Marisa REPETTO2 *
BIOCELL, Vol.40, No.1, pp. 19-22, 2016, DOI:10.32604/biocell.2016.40.019
Abstract The objective of this work was to study the in vivo time course of biochemical processes of oxidative
damage in the brain of Sprague-Dawley rats that received an acute overload of the redox active metals iron (Fe)
and copper (Cu), and the redox inactive cobalt (Co) and nickel (Ni). Oxidative stress indicators (phospholipid and
protein oxidation), glutathione (GSH), antioxidant enzymes and NADPH oxidase activities, and the plasma inflammatory cytokine (IL-6) were measured. The results showed that in brain oxidative mechanisms for both sets of metal
are different, however in both cases are irreversible. The mechanism for Fe and Cu oxidative… More >
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