JI ZHU#, XIYING BO#, GENGXI JIANG, SHIHUA YAO, TIEJUN ZHAO*, LING CHEN*
BIOCELL, Vol.45, No.3, pp. 639-647, 2021, DOI:10.32604/biocell.2021.012847
Abstract Non-small cell lung cancer (NSCLC) cells intake and consume glucose at high efficiency by aerobic glycolysis to
maintain robust cell growth and resist cell death. MicroRNAs (miRNAs) have been known to play pivotal roles in NSCLC
development partly through mediating glycolysis. However, only a few miRNAs have been experimentally confirmed as
critical regulators of glycolysis in NSCLC. TCGA datasets were analyzed to screen for differentially expressed miRNAs
between NSCLC and normal tissues. The function of miR-1294-5p was determined in NSCLC cells by cell
proliferation, glucose uptake, lactate release, and Extracellular Acidification Rate (ECAR) assays. The target of miR-
1294-5p was… More >
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