Qin Liu*†, Wei Wang†, Fangqiong Li†, Dongyang Yu‡, Chunfen Xu*, Hongbing Hu*
Oncology Research, Vol.27, No.9, pp. 1043-1050, 2019, DOI:10.3727/096504019X15560124931900
Abstract Triptolide, an extract of Tripterygium wilfordii, has been shown to have a potent anticancer activity. In the
present study, it was found that triptolide could effectively induce apoptosis and inhibit proliferation and invasion in malignant MDA-MB-231 breast cancer cells. The study focused on its effect on inhibiting invasion,
which has not been extensively reported to date. We predicted that triptolide may change invasion activity via
microRNAs (miRNAs), which have been recognized as important regulators of gene expression. miRNAome
variation in MDA-MB-231 cells with or without triptolide treatment demonstrated that miR-146a was upregulated following treatment with triptolide. Our previous studies have… More >
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