SALONI THAKUR1, ADESH K. SAINI2,3, JOYDEEP DAS4, VIPIN SAINI3, PARIN BALHARA5, JAGPREET S. NANDA6, REENA V. SAINI2,3
BIOCELL, Vol.46, No.1, pp. 13-26, 2022, DOI:10.32604/biocell.2022.016953
Abstract MicroRNA-153 (miR-153), belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3’UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs.… More >
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