ZHIHENG LIU1,2, ZHEN SUN3, ZHONGYUAN WAN4, HAIQIANG WANG2,*
BIOCELL, Vol.46, No.2, pp. 511-517, 2022, DOI:10.32604/biocell.2021.016194
Abstract We unraveled the expression profiles of coding-noncoding RNAs in intervertebral disc degeneration (IDD).
However, it remains elusive regarding miR-155 expression in peripheral blood mononuclear cells (PBMCs) and local
extracellular space in IDD. The study aimed for investigating the miR-155 expression of PBMCs, extracellular
miRNAs (ex-miRNAs) of human nucleus pulposus (NP) tissues, and morphological changes of cell death in the IDD
process. Here, we harvested peripheral blood and NP samples from scoliosis and IDD patients as control and
degenerative groups, respectively. Then standard Ficoll density-gradient centrifugation was used to isolate PBMCs.
The two subpopulations of PBMCs were divided based on the… More >
Login
Register
