JUNQI GUO1,2,#, YUN YANG1,2,#, WEI ZHAO1,2, ZHONGHAI YAN3, XIA YANG4, YUNFEI YAN1,2, RUIMIN HAO1,2, JINXIA HU1,2,*, FEI JIAO1,2,*
BIOCELL, Vol.45, No.3, pp. 627-638, 2021, DOI:10.32604/biocell.2021.013496
Abstract Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer
progression. However, the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer
(NSCLC) are not to be well studied. Here, we validated that the expression of miR-16-5p was decreased significantly
in NSCLC samples and cell lines. The correlation between the clinicopathological features of NSCLC and the miR-16-
5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced
TNM stage, positive lymph node metastasis, with short overall survival (OS). Also, a negative correlation between
miR-16-5p and Fermitin… More >
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