Yankun Zhang*, Wei Qian*, Feng Feng†, Qian Cao*, Yanqi Li*, Ying Hou*,
Luyang Zhang*, Jufeng Fan*
Oncology Research, Vol.27, No.3, pp. 371-377, 2019, DOI:10.3727/096504018X15178740729367
Abstract This study aimed to investigate the effect and underlying mechanism of lncRNA CASC2 in malignant melanoma (MM). Expression of CASC2 in MM tissues and cells was detected. A375 cells were transfected with
pc-CASC2, si-CASC2, miR-18a-5p inhibitor, or corresponding controls, and then cell proliferation, migration,
and invasion were detected using MTT assay, colony formation assay, and Transwell analysis, respectively.
The relationship of miR-18a-5p and CASC2 or RUNX1 was detected by luciferase reporter assay. The levels
of CASC2 and RUNX1 were significantly reduced in MM tissues compared with normal skin tissues or cells,
while the miR-18a-5p level was obviously increased (all p<0.01).… More >
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