Wei Ni*†‡, Lin Luo*†‡, Ping Zuo*†‡, Renping Li*†‡, Xiaobing Xu*†‡, Fan Wen*†‡, Dong Hu*†‡
Oncology Research, Vol.27, No.6, pp. 703-712, 2019, DOI:10.3727/096504018X15426775024905
Abstract Glioma is a commonly diagnosed brain tumor that shows high mortality rate. Despite the great advancement of
cancer therapy in recent years, chemotherapy is still an important approach for treatment of glioma. However,
long-term chemotherapy usually causes serious side effects or complications. It is desirable to take strategies
to enhance the efficacy of current chemotherapy. In the present study, we observed obvious upregulation of
miR-374a in glioma cells. More importantly, we found that knockdown of miR-374a was able to enhance the
etoposide-induced cytotoxicity against glioma cells. Mechanically, we demonstrated that FOXO1 was the target of miR-374a in glioma. Treatment with… More >
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