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    ARTICLE

    Knockdown of lncRNA PVT1 Inhibits Glioma Progression by Regulating miR-424 Expression

    Yanjie Han*1, Xinxin Li*1, Fei He†1, Jiliang Yan*, Chunyan Ma*, Xiaoli Zheng, Jinli Zhang*, Donghui Zhang*, Cuiping Meng*, Zhen Zhang*, Xinying Ji§

    Oncology Research, Vol.27, No.6, pp. 681-690, 2019, DOI:10.3727/096504018X15424939990246

    Abstract Plasmacytoma variability translocation 1 (PVT1), an oncogene, has been reported to be highly expressed in many tumors, including human glioma, gastric cancer, and non-small cell lung cancer. Functionally, it could also regulate the development of tumor cells. However, its specific roles and pathogenesis in human gliomas are still not clear. This study investigated the function and mechanism of PVT1 knockdown in the proliferation and malignant transformation of human gliomas. We first examined the expression levels of PVT1 and miR- 424 in human glioma tissues and cell lines. We also used gene manipulation techniques to explore the effects of PVT1 knockdown… More >

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