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    miR-455 Functions as a Tumor Suppressor Through Targeting GATA6 in Colorectal Cancer

    Hua Yunqi*1, Yin Fangrui†1, Yang Yongyan*, Jin Yunjian*, Zhang Wenhui*, Cao Kun*, Li Min*, Liu Xianfeng*, Ba Caixia*

    Oncology Research, Vol.27, No.3, pp. 311-316, 2019, DOI:10.3727/096504018X15220579006875

    Abstract Emerging evidence indicates that microRNAs (miRNAs) are often aberrantly expressed in human cancers. Meanwhile, the importance of miRNAs in regulating multiple cellular biological processes has been appreciated. The aim of this study was to investigate the significance of miR-455 and identify its possible mechanism in regulating colorectal cancer (CRC) progression. We found that the expression of miR-455 was sharply reduced in CRC tissues and cell lines. Importantly, the low expression of miR-455 was associated with poor overall survival of CRC patients. Overexpression of miR-455 in CRC cell lines significantly inhibited cell proliferation and migration in More >

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