ZiJun Liao*†, Qi Zheng†, Ting Wei‡, YanBing Zhang†, JieQun Ma†, Zheng Zhao§,
HaiFeng Sun§, KeJun Nan*
Oncology Research, Vol.28, No.2, pp. 147-159, 2020, DOI:10.3727/096504019X15732109856009
Abstract MicroRNAs (miRNAs) play crucial roles in tumorigenesis and tumor progression. miR-561 has been reported
to be downregulated in gastric cancer and affects cancer cell proliferation and metastasis. However, the role and
underlying molecular mechanism of miR-561 in human non-small cell lung cancer (NSCLC) remain unknown
and need to be further elucidated. In this study, we discovered that miR-561 expression was downregulated
in human NSCLC tissues and cell lines. The overexpression of miR-561 inhibited NSCLC cell proliferation
and cell cycle G1
/S transition and induced apoptosis. The inhibition of miR-561 facilitated cell proliferation
and G1
/S transition and suppressed apoptosis. miR-561… More >
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