HONGXIA HU*, PING GUO, QIAN ZHAO, HAORAN LI, HUALEI LIU, CAIHONG MA
BIOCELL, Vol.45, No.4, pp. 995-1004, 2021, DOI:10.32604/biocell.2021.012851
Abstract This study aims to detect the expression of selected circulating microRNAs (miRNA), including miRNA-451a,
miRNA-486-5p and miR-10b-5p, and their prospective roles as biomarkers in patients with atherosclerosis. For this
purpose, levels of miRNAs were detected by real-time quantitative polymerase chain reaction (RT-qPCR) in case (N =
30) and healthy control (N = 30) groups. Receiver operating characteristic (ROC) curve analysis was carried out to
evaluate the diagnostic ability of miRNAs. The correlations of miR-451a with lipid parameters were evaluated using
Pearson’s correlation coefficients. HUVEC tested by ox-LDL was used as a cellular model of atherosclerosis. Cell
viability and apoptosis were… More >
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