Megumi Baba1, Aya Shinmura1, Shigeru Tada1, Taku Amo2, Akira Tsukamoto1,*
Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 1-12, 2019, DOI:10.32604/mcb.2019.05199
Abstract Mitochondria in endothelial cells remodel morphologically when supraphysiological cyclic stretch is exerted on the cells. During remodeling, mitochondria become shorter, but how they do so remains elusive. Drp1 is a regulator of mitochondrial morphologies. It shortens mitochondria by shifting the balance from mitochondrial fusion to fission. In this study, we hypothesized that Drp1 activation is involved in mitochondrial remodeling under supraphysiological cyclic stretch. To verify the involvement of Drp1, its activation was first quantified with Western blotting, but Drp1 was not significantly activated in endothelial cells under supraphysiological cyclic stretch. Next, Drp1 activation was inhibited with Mdivi-1, but this did… More >
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