Submit

Login Login

Register Register

Home / Advanced Search
News & Announcements

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
Show export options
  • Articles
  • Online
Search Results (2)

  • Open Access

    ARTICLE

    Antibody targeting TSLP suppresses DSS-induced colitis and activation of the JAK2/STAT5 pathway in mice

    Wei Zhuang, Zhen Li

    European Cytokine Network, Vol.34, No.4, pp. 46-53, 2023, DOI:10.1684/ecn.2023.0489

    Abstract Background: There is currently no safe or effective treatment for inflammatory bowel disease (IBD), which is defined as recurrent and persistent intestinal inflammation. Thymic stromal lymphopoietin (TSLP) has been shown to be associated with the pathogenesis of IBD, and the JAK2/STAT5 signalling pathway has demonstrated much promise as a novel therapeutic target for IBD. Materials and Methods: In this study, we first evaluated levels of TSLP in dextran sodium sulphate (DSS)-induced IBD mice. Second, we applied tezepelumab, an anti-TSLP monoclonal antibody (20 µg per mouse, intraperitoneally), to DSS-induced IBD mice and quantified the signs of histopathological change,… More >

    View

    78

    Download

    101

  • Open Access

    ABSTRACT

    Autodigestion in Physiological Shock, Organ Dysfunction and Death

    Erik B. Kistler1, Geert W. Schmid-Schönbein2,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 8-8, 2019, DOI:10.32604/mcb.2019.07256

    Abstract A longstanding question in research on organ failure after physiological shock (such as trauma, burns, sepsis, surgery and medical emergencies) is the underlying mechanism for a progressive loss of cell and tissue functions. Our systematic analysis of this problem has served to identify digestive enzymes as key players [1, 2]. After synthesis and discharge from the pancreas, the digestive enzymes are usually contained inside the lumen of the small intestine where they break down food every day. Escape of the digestive enzymes out of the lumen of the intestine is kept to a minimum by… More >

    View

    4170

    Download

    1700

Displaying 1-10 on page 1 of 2. Per Page  

Contact Us

Copyright© 2026 Tech Science Press
© 1997-2026 TSP (Henderson, USA) unless otherwise stated