Sharaf J. Malebary¹, Yaser Daanial Khan^2,*

CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 2863-2881, 2021, DOI:10.32604/cmc.2021.015041

Abstract With the advancement in cellular biology, the use of antimicrobial peptides (AMPs) against many drug-resistant pathogens has increased. AMPs have a broad range of activity and can work as antibacterial, antifungal, antiviral, and sometimes even as anticancer peptides. The traditional methods of distinguishing AMPs from non-AMPs are based only on wet-lab experiments. Such experiments are both time-consuming and expensive. With the recent development in bioinformatics more and more researchers are contributing their effort to apply computational models to such problems. This study proposes a prediction algorithm for classifying AMPs and distinguishing between AMPs and non-AMPs. The proposed methodology uses machine… More >

Yuan LI¹, Yonghyun LEE², Yielhea SEO³, Youjin HWANG^{1, 2, *}

BIOCELL, Vol.43, No.4, pp. 263-269, 2019, DOI:10.32604/biocell.2019.07664

Abstract The aim of this study was to determine the relationship between phenotypic antimicrobial susceptibility patterns and extended-spectrum, carbapenem-resistance genes. A total of 109 clinical Staphilococcus aureus strains were subjected to 19 antimicrobial susceptibility tests. Resistance to methicillin (mecA), penicillin (blaTEM), and tetracycline (tetM) was detected. We compared the presence of the blaTEM genes with extended-spectrum, carbapenem-related genes and identified the types of SCCmec genes. Of 109 clinical S. aureus strains, 62 (56.88%) had methicillin resistance and 60 strains carried mecA. The prevalence of blaTEM and tetM genes was 81.65% and 37.61%, respectively. The most predominant SCCmec type was SCCmec type… More >

Haifeng WANG^{1, 2, 3} , Hongxuan HE²

BIOCELL, Vol.42, No.2, pp. 47-54, 2018, DOI:10.32604/biocell.2018.07006

Abstract The emergence and spread of antibiotic resistance genes among Bacteria are a serious threat to global health. Their occurrence in animals which are in contact with humans is also important. The Chinese cobra (Naja atra, Elapidae), though a highly venomous species, is appreciated as food and as a source of materials used in traditional Chinese medicine. We are here reporting the isolation of multidrug-resistant Klebsiella pneumoniae (Enterobacteriaceae) from the lung of Naja atra, obtained from a snake farm in a Beijing suburb. Our study analyzed, using gene sequencing, the occurrence of antibiotic resistance genes (ARGs) in three K. pneumoniae… More >