Shiwei Zhao^1,*, Hao Chen², Jidong Zhao¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09965

Abstract With global warming, thaw-induced landslides occur more frequently in permafrost, which not only threaten the safety of infrastructures as general geohazards but also worsen global warming due to carbon release. This work presents a novel computational framework to model thaw-induced landslides from a multiscale perspective. The proposed approach can capture the thermal-mechanical (TM) response of frozen soils at the particulate scale by using discrete element method (DEM). The micromechanics-based TM model is superior to capturing the sudden crash of soil skeletons caused by thaw-induced cementation loss between soil grains. The DEM-simulated TM response is then homogenized and directly fed into… More >

Rina Okuyama¹, Naoto Mitsume², Hideki Fujii¹, Hideaki Uchida^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.3, pp. 949-965, 2021, DOI:10.32604/cmes.2021.015773

Abstract As the number of automobiles continues to increase year after year, the associated problem of traffic congestion has become a serious societal issue. Initiatives to mitigate this problem have considered methods for optimizing traffic volumes in wide-area road networks, and traffic-flow simulation has become a focus of interest as a technique for advance characterization of such strategies. Classes of models commonly used for traffic-flow simulations include microscopic models based on discrete vehicle representations, macroscopic models that describe entire traffic-flow systems in terms of average vehicle densities and velocities, and mesoscopic models and hybrid (or multiscale) models incorporating both microscopic and… More >

Padmini Rangamani^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 22-22, 2019, DOI:10.32604/mcb.2019.08513

Abstract Endocytosis is the process of uptake of cargo and fluid from the extracellular space to inside the cell; defects in endo- cytosis contribute to a wide spectrum of diseases including cancer, neurodegeneration, and heart disease. Clathrin- mediated endocytosis (CME) is an archetypal example of a membrane deformation process where multiple variables such as pre-existing membrane curvature, membrane bending due to the protein machinery, membrane tension regulation, and actin-mediated forces govern the progression of vesiculation. My group has been working for the past few years on deciphering the biophysical determinants of CME using multiscale modeling. We recently showed that membrane tension… More >

Mikhail Itskov*, Khiȇm Ngoc Vu

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.1, pp. 112-112, 2019, DOI:10.32604/icces.2019.05013

Abstract Mechanoluminescence is a phenomenon where broken chemical bonds send out visible light upon stress application. To this end, special mechanophores are added into the polymer network prior to its vulcanization. As such, bis(adamantyl) 1,2-dioxetane can be used. The breakage of the dioxetane cross-linker is irreversible and can directly be used to assess the damage evolution in rubber-like materials. The intensity of the emitted light correlates with the underlying evolution of chain scission in polymers. In this contribution, an anisotropic analytical network-averaging concept [1] is utilized to model mechanoluminescence, Mullins effect, hysteresis and induced anisotropy in mechano-chemically responsive polymeric materials [2].… More >

K.G. Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.3, No.1, pp. 21-28, 2007, DOI:10.3970/icces.2007.003.021

Abstract A framework of applications of multiscale modeling to property prediction of advanced materials will be briefly presented. A methodology will be shown to link micro-scale to the continuum scale, integrating micro-scale modeling of microstructure with the large Thermo-Calc© database. This paradigm is successfully applied to the case of Fe-12Ni-6Mn maraging steel. We predict the mechanical properties of the maraging steel such as hardness. We found that our predictions in hardness is in agreement with experimental data. More >

Peter W. Chung¹, Raju R. Namburu², Brian J. Henz³

CMES-Computer Modeling in Engineering & Sciences, Vol.5, No.1, pp. 45-62, 2004, DOI:10.3970/cmes.2004.005.045

Abstract A method is developed based on an additive modification to the first Lagrangian elasticity tensor to make the finite element method for hyperelasticity viable at the atomic length scale in the context of lattice statics. Through the definition of an overlap region, the close-ranged atomic interaction energies are consistently summed over the boundary of each finite element. These energies are subsequently used to additively modify the conventional material property tensor that comes from the second derivative of the stored energy function. The summation over element boundaries, as opposed to atom clusters, allows the mesh and nodes to be defined independently… More >

Yoshitaka Shimada^∗,†, Taiji Adachi^∗,†,‡, Yasuhiro Inoue^∗,†, Masaki Hojo^∗

Molecular & Cellular Biomechanics, Vol.6, No.3, pp. 161-174, 2009, DOI:10.3970/mcb.2009.006.161

Abstract The actin filament, which is the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities such as shape determination, cell motility, and mechanosensing. In each activity, the actin filament dynamically changes its structure by polymerization, depolymerization, and severing. These phenomena occur on the scales ranging from the dynamics of actin molecules to filament structural changes with its deformation due to the various forces, for example, by the membrane and solvent. To better understand the actin filament dynamics, it is important to focus on these scales and develop its mathematical model. Thus, the objectives of this study… More >

D. Chrupalla¹, J. Kreikemeier¹, S. Berg², L. Kärger³, M. Doreille⁴, T. Ludwig⁴, E. Jansen², R. Rolfes², A.Kling¹

CMC-Computers, Materials & Continua, Vol.32, No.3, pp. 159-176, 2012, DOI:10.3970/cmc.2012.032.159

Abstract In this paper, a loose coupling multiscale modeling technique for the detailed numerical analysis of critical areas in composite structures is presented. It is used to describe the global (macroscopic) behaviour of composite structures taking into account the effects of local phenomena. This is done by indirectly connecting the global and local FE-models. Prescribed displacements are assigned to the local boundaries in the transition from the global to local modeling level. The local-to-global transition is realized by assigning averaged local stresses to the respective global Gauss points and by updating the global tangent stiffness operator. To illustrate the feasibility of… More >

Marcin Maździarz¹, Marcin Gajewski²

CMES-Computer Modeling in Engineering & Sciences, Vol.105, No.2, pp. 123-150, 2015, DOI:10.3970/cmes.2015.105.123

Abstract In this paper, the choice and parametrisation of finite deformation polyconvex isotropic hyperelastic models to describe the behaviour of a class of defect-free monocrystalline metal materials at the molecular level is examined. The article discusses some physical, mathematical and numerical demands which in our opinion should be fulfilled by elasticity models to be useful. A set of molecular numerical tests for aluminium and tungsten providing data for the fitting of a hyperelastic model was performed, and an algorithm for parametrisation is discussed. The proposed models with optimised parameters are superior to those used in non-linear mechanics of crystals. More >

V.B.Shim ¹, K. Mithraratne ¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.3, pp. 279-294, 2014, DOI:10.32604/cmes.2014.098.279

Abstract The activation of NF-kB is an important precursor in developing melanoma. However the role of mechanical stimulation in the NF-kB activation has not been studied. We used a multiscale computational modeling approach to investigate the role of mechanical stimulation and the skin tissue internal structures in the activation of NF-kB. Our model is made up of three levels – 1) the macro level where a FE model of the Zygomaticus major muscle was developed; 2) the meso level where a micro FE model of the skin block using a sample from human cadaver was developed; 3) the cell level where… More >