Liqiong Ding¹, Pingsheng Li², Liu He¹, Fengnan Xu¹, Jieqiong Ding^3,*, Binhua Luo^1,*

Journal of Renewable Materials, Vol.10, No.3, pp. 767-780, 2022, DOI:10.32604/jrm.2022.016903

Abstract The development of contrast agents that can be activated by multiple modes is of great significance for tumor diagnosis. In this study, the lactoferrin (Lf)-conjugated polylactic acid (PLLA) nanobubbles (Lf-PLLA NBs) were used to encapsulate liquid perfluoropentane (PFP) with the double emulsion method, creating PFP loaded (PFP/Lf-PLLA) NBs for the ultrasound/magnetic resonance dual-modality imaging of subcutaneous tumor. The particle diameter and stability of nanobubbles were investigated by photon correlation spectroscopy. The biocompatibility of nanobubbles was preliminarily evaluated by cell proliferation and migration assay, hemolysis rate, and blood biochemistry analysis. A B-mode clinical ultrasound real-time imaging system was used to perform… More >

Prabhakar Misra¹, Silvina M. Gatica¹, Obafemi Otelaja²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.5, No.4, pp. 205-210, 2008, DOI:10.3970/icces.2008.005.205

Abstract Nanobubbles form either spontaneously or by induction at the surface of certain solids immersed in a liquid. Atomic Force Microscopy observations have confirmed their formation. Such bubbles have sizes in the range 10-100 nm and have important ramifications for properties of interfaces and could be responsible for long-range hydrophobic attractive forces. In addition, as a potential application, the use of nanobubbles -- in tandem with ultrasound -- has been proposed for the treatment of strokes. Formation of nanobubbles at the water-graphite interface influences the adsorption of nanoparticles and the corresponding wetting properties. An important parameter relevant to the stability of… More >

H. Elnaiem¹, D. Casimir¹, P. Misra¹, S.M. Gatica^1,2

CMC-Computers, Materials & Continua, Vol.14, No.1, pp. 23-34, 2009, DOI:10.3970/cmc.2009.014.023

Abstract Nanobubbles have been found to form at the interface of water and solid surfaces. We examine the conditions for such bubbles to form and estimate the pressure inside the bubble based on thermodynamic considerations. Using a simple model we calculate the contact angle for a wide range of temperatures and hypothetical substrates possessing a continuous range of strengths. We show that as the temperature increases the shape of a bubble changes continuously from a spherical cap with low curvature to a complete sphere. An equivalent effect results from either increasing the strength of the solid or decreasing the surface tension.… More >