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    AFM and Nanoindentation Studies of Bone Nodules on Chitosan-Polygalacturonic Acid-Hydroxyapatite Nanocomposites

    R. Khanna1,2, D. R. Katti1, K. S. Katti1

    CMES-Computer Modeling in Engineering & Sciences, Vol.87, No.6, pp. 530-556, 2012, DOI:10.3970/cmes.2012.087.530

    Abstract Here we report a new in situ nanoindentation technique developed to evaluate the composite mechanical behavior of cell-biomaterial construct under physiological conditions over the time scale of bone nodule generation. Using this technique, mechanical behavior of osteoblast cell-substrate interfaces on tissue engineered materials (chitosan-polygalacturonic acid-nanohydroxyapatite (CPH) films) is investigated. Mechanical behavior of cells in the elastic regime over the time scale of cell adhesion (1 day), proliferation (4 days), development (8 days) and maturation (22 days) of bone nodules is evaluated. Our results indicate that the elastic properties of flat cells are higher (indicating stiffer response, after 4 days, as… More >

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