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  • Open Access

    ARTICLE

    Implementation of a Pediatric Oncology Precision Medicine Clinic to Personalize Approaches for Diagnosing and Treating Solid Tumors

    Madeline Keane1, Natalia Wojciechowska2, Lindsay Zumwalt1,*, Emilie Sandfeld3, Alejandra Dominguez1, Jason Wang2, Anish Ray2

    Oncology Research, Vol.33, No.8, pp. 1895-1908, 2025, DOI:10.32604/or.2025.065547 - 18 July 2025

    Abstract Background: Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments. The study aimed to outline the establishment and impact of a Precision Medicine Clinic (PMC) in the setting of pediatric oncology, with the objective of offering targeted treatment options within the institution and creating a scalable model for adoption by other healthcare systems to achieve a wider impact. Methods: Recognizing this need for an individualized approach to treating patients, Cook Children’s Medical Center (CCMC) established a multidisciplinary molecular… More >

  • Open Access

    ARTICLE

    The Investigation of Genotype-Phenotype Relationship in Multiple Primary Malignant Neoplasia Patients

    Neslihan Duzkale1,*, Emine Demıral2

    Oncologie, Vol.22, No.4, pp. 225-234, 2020, DOI:10.32604/oncologie.2020.014120

    Abstract Multiple primary malignant neoplasms (MPMN) are rare tumors that have attracted attention with increasing incidence rates in recent years and where cancer susceptibility genes may play a role in their etiology. In this study, it was aimed to determine the genotype-phenotype correlation in patients with MPMN. From January 2018 to January 2020, thirty patients were analyzed for 59 cancer susceptibility genes and diagnosed with MPMN, using a large multigene panel with Next Generation Sequencing technique (NGS) in Turkey. The mean age of first and second cancer diagnosis of cases were calculated as 42.5 and 49.9… More >

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