Xiaolin Wu, Lanping Diao, Guimin Zhao, Chen Huang, Yingzhen Yao, Zhe Gao, Lili Wu*
Oncologie, Vol.23, No.1, pp. 141-148, 2021, DOI:10.32604/Oncologie.2021.014790
Abstract This study aimed to investigate the relationship and diagnostic potential between microsatellite instability (MSI) caused by a 9-bp GGGGGTAGA insertion/deletion in mitochondrial DNA (mtDNA) at position 8272 and clinical features in Chinese patients diagnosed with non-Hodgkin’s lymphoma. The 9-bp GGGGGTAGA insertion/deletion in the non-d-loop area of the mitochondrial DNA at the 8272 locus was detected by PCR in 139 non-Hodgkin’s lymphoma patient samples. GGGGGTAGA insertion/deletion was found in a total of 16 cases (11.5%), including nine T cell lymphoma and seven B cell lymphoma cases. The 5-year survival rate was 33.3% in patients with non-Hodgkin’s lymphoma and MSI, and was… More >
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