LUCIANA MAZZEI1, ISABEL MERCEDES GARCÍA1, VALERIA CACCIAMANI1, MARÍA EUGENIA BENARDÓN1 AND WALTER MANUCHA1, 2, 3
BIOCELL, Vol.34, No.3, pp. 121-132, 2010, DOI:10.32604/biocell.2010.34.121
Abstract Wilms tumor gene 1 (wt-1), a key regulator of mesenchymal-epithelial transformation, is downregulated during congenital obstructive nephropathy, leading to apoptosis. There is a functional interaction between WT-1 and inducible nitric oxide synthase (iNOS). In this regard, we reported that after neonatal unilateral ureteral obstruction, rosuvastatin prevents apoptosis through an increase in nitric oxide bioavailability, which in turn is linked to higher Hsp70 expression. Hence, the goal of this study was to determine whether a nitric oxide/Hsp70 interaction is involved in changes in WT-1 mRNA expression after ureteral obstruction. Neonatal rats submitted to experimental ureteral obstruction were treated with either vehicle… More >
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