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  • Open Access

    ARTICLE

    Associations between Mental Health Outcomes and Adverse Childhood Experiences and Character Strengths among University Students in Southern China

    Yulan Yu1,2, Rassamee Chotipanvithayakul3, Hujiao Kuang4, Wit Wichaidit3,*, Chonghua Wan1,2,*

    International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1343-1351, 2023, DOI:10.32604/ijmhp.2023.043446

    Abstract Adverse childhood experiences (ACEs) can negatively affect mental health, whereas character strengths seem to be positively correlated with mental health. Detailed information on the history of ACEs among university students in China and the extent which mental health is associated with ACEs and character strengths can contribute to the needed empirical evidence for relevant stakeholders. Objectives of this study are 1) to estimate the prevalence of ACEs among undergraduate students in Southern China; and 2) to assess the extent which mental health outcomes (positive growth, well-being, and depression) are associated with ACEs and character strengths among undergraduate students in Southern… More >

  • Open Access

    ARTICLE

    Leveraging diverse cell-death patterns to predict the clinical outcome of immune checkpoint therapy in lung adenocarcinoma: Based on muti-omics analysis and vitro assay

    HONGYUAN LIANG1,#, YANQIU LI2,#, YONGGANG QU3, LINGYUN ZHANG4,*

    Oncology Research, Vol.32, No.2, pp. 393-407, 2024, DOI:10.32604/or.2023.031134

    Abstract Advanced LUAD shows limited response to treatment including immune therapy. With the development of sequencing omics, it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response markers. Using GSE72094 (n = 386) and GSE31210 (n = 226) gene expression profile data in the GEO database, we identified genes associated with lung adenocarcinoma (LUAD) death using tools such as “edgeR” and “maftools” and visualized the characteristics of these genes using the “circlize” R package. We constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression methods. By calculating the cell death… More >

  • Open Access

    REVIEW

    A perspective on molecular and cellular biology-based developmental toxicology biomarkers

    SUKHENDU DEY1,#, SANDIPAN PAL2,#, APURBA RATAN GHOSH1, PALAS SAMANTA3,*

    BIOCELL, Vol.47, No.12, pp. 2579-2590, 2023, DOI:10.32604/biocell.2023.031114

    Abstract The process of development is intricate and couple-dependent phenomenon. Accordingly, the study of molecular and cellular biology-based developmental toxicology biomarkers increasingly is becoming an important part of risk assessment and management of chemicals for detection of health outcomes and/or biological endpoint like cytotoxicity, cell death, etc. Since, the evolution of developmental toxicology field a number of tools/markers have been developed or addressed to deal with developmental outcomes, which can ultimately be used for the development of adverse outcome pathways (AOPs) of developmental toxicants. As a result, this paper provides an overview of the current state of developmental toxicology biomarkers and… More >

  • Open Access

    REVIEW

    Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

    QIUQIANG CHEN1,*, XUEJUN GUO2, WENXUE MA3,*

    Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

    Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

    Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

  • Open Access

    ARTICLE

    Analysis of Risk Factors for Early Mortality in Surgical Shunt Palliation: Time for a Change?

    François-Xavier Van Vyve1, Karlien Carbonez2, Jelena Hubrechts2, Geoffroy de Beco1, Jean E. Rubay1, Mona Momeni3, Thierry Detaille4, Alain J. Poncelet1,*

    Congenital Heart Disease, Vol.18, No.5, pp. 539-550, 2023, DOI:10.32604/chd.2023.042344

    Abstract Objectives: Over the last decade, neonatal repair has been advocated for many congenital heart diseases. However, specific subgroups of complex congenital heart disease still require temporary palliation for which both surgical and endovascular techniques are currently available. We reviewed our institutional experience with shunt palliation with an emphasis on risk factors for early mortality. Methods: This is a single-center retrospective study on 175 patients undergoing surgery for central shunt or modified Blalock-Taussig shunt. All data were extracted from a prospectively collected computerized database. We identified risk factors for early mortality by uni- and multi-variable analysis. All data were censored at… More >

  • Open Access

    ARTICLE

    Analysis of Pulmonary Arteries Growth after Initial Shunt Palliation in Neonates and Infants

    François-Xavier Van Vyve1,#, Karlien Carbonez2,#, Geoffroy de Beco1, Stéphane Moniotte2, Jean E. Rubay1, Mona Momeni3, Laurent Houtekie4, Alain J. Poncelet1,*

    Congenital Heart Disease, Vol.18, No.5, pp. 525-537, 2023, DOI:10.32604/chd.2023.042341

    Abstract Objective: Despite increasing enthusiasm for neonatal repair, patients with ductal-dependent circulation (pulmonary/systemic) or restrictive pulmonary blood flow still require initial palliation. Ductal stenting has emerged as an endovascular approach whereas modified-Blalock-Taussig and central shunt remain surgical references. In this study, we analyzed the relationship between pulmonary artery growth, sites of shunt connection, or antegrade pulmonary blood flow in surgically placed shunts. The need for secondary catheter-based interventions or pulmonary arterioplasty was also investigated. Methods: A retrospective single-center study analyzing 175 patients undergoing surgery for a central or modified-Blalock-Taussig shunt. Outcome growth variables were right pulmonary artery/left pulmonary artery diameters/Z scores,… More > Graphic Abstract

    Analysis of Pulmonary Arteries Growth after Initial Shunt Palliation in Neonates and Infants

  • Open Access

    ARTICLE

    Break Free from Depression: Implementation and Outcomes of a School-Based Depression Awareness Program

    Amy J. Kaye1,*, Vanessa Prosper2, Kathryn Moffa1, Vanja Pejic1, Karen Capraro1, Georgios D. Sideridis1, Abigail Ross1,3, Kristine M. Dennery1, David R. DeMaso1

    International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1103-1115, 2023, DOI:10.32604/ijmhp.2023.030185

    Abstract The objective of this study was to evaluate the impact of Break Free from Depression (BFFD), a school-based depression awareness curriculum, in comparison to a wait list control group. A total of 13 eighth grade classrooms participated in either an intervention or control group and completed pre-, post-, and three-month follow-up surveys. Students participating in BFFD (N = 6 classrooms, 166 students) demonstrated enhanced knowledge of and more adaptive attitudes towards depression compared to the control group (N = 7 classrooms, 155 students). Participants in the BFFD intervention also demonstrated increases in their confidence in knowing how to seek help… More >

  • Open Access

    ARTICLE

    Long-Term Outcomes of Systemic-to-Pulmonary Artery Shunt in Patients with Functional Single Ventricle and Heterotaxy Syndrome

    Shota Kawai1, Takashi Kido1,*, Yuta Teguri1, Koji Miwa1, Tomomitsu Kanaya1, Yoichiro Ishii2, Hisaaki Aoki2, Futoshi Kayatani2, Sanae Tsumura1

    Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243

    Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04), but the statistical significance… More >

  • Open Access

    ARTICLE

    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

    Daniel Sweeney1, Scott Cohen2,3, Salil Ginde2,3, Jennifer Gerardin2,3, Peter Bartz2,3, Matthew Buelow2,3,*

    Congenital Heart Disease, Vol.18, No.3, pp. 315-323, 2023, DOI:10.32604/chd.2023.027349

    Abstract Background: Women with congenital heart disease (CHD) have increased risk for adverse events during pregnancy and delivery. Prior studies have assessed pregnancy and delivery outcomes at tertiary referral centers (TRC). The aim of our study was to assess pregnancy outcomes in women with CHD who deliver in a non-tertiary referral center (non-TRC). Methods: Clinical demographics were collected, including anatomic complexity, physiologic state and pre-pregnancy risk assessment. Patients were stratified by delivery location, either TRC or non-TRC. Maternal and neonatal complications of pregnancy were reported. Results: Women with CHD who delivered in a TRC had a higher pre-pregnancy risk when assessed… More > Graphic Abstract

    Delivery Outcomes in Non-Tertiary Referral Centers for Women with Congenital Heart Disease

  • Open Access

    ARTICLE

    Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

    Henry P. Foote1, Huali Wu2, Stephen J. Balevic1,2, Elizabeth J. Thompson1,2, Kevin D. Hill1,2, Eric M. Graham3, Christoph P. Hornik1,2, Karan R. Kumar1,2,*

    Congenital Heart Disease, Vol.18, No.3, pp. 295-313, 2023, DOI:10.32604/chd.2023.026262

    Abstract Background: Infants undergoing cardiac surgery with cardiopulmonary bypass (CPB) frequently receive intra-operative methylprednisolone (MP) to suppress CPB-related inflammation; however, the optimal dosing strategy and efficacy of MP remain unclear. Methods: We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our institution. We combined real-world dosing data from the electronic health record (EHR) and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration (Cmax) and area under the concentration-time curve for 24 h (AUC24) for MP and the inflammatory cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10). We evaluated the relationships… More > Graphic Abstract

    Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates

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