Jae Hong Lee¹, Sungkyu Cho^2,*, Jae Gun Kwak², Hye Won Kwon², Woong-Han Kim², Mi Kyoung Song³, Sang-Yun Lee³, Gi Beom Kim³, Eun Jung Bae³

Congenital Heart Disease, Vol.19, No.1, pp. 69-83, 2024, DOI:10.32604/chd.2024.045137

Abstract Background: The optimal surgical timing and clinical outcomes of ventricular septal defect (VSD) closure in neonates remain unclear. We aimed to evaluate the clinical outcomes of VSD closure in neonates (age ≤ 30 days). Methods: We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June 2021. Indications for the procedure included congestive heart failure/failure to thrive and pulmonary hypertension. Major adverse events (MAEs) were defined as the composite of all-cause mortality, reoperation, persistent atrioventricular block, and significant (≥grade 2) valvular dysfunction. Results: The median age and body weight at operation were 26.0… More >

MENNA AL-ADL^1,*, MAGDY M. YOUSSEF¹, AHMED EL-SEBAIE², SHERIF REFAAT³, AFAF EL-SAID⁴

Oncology Research, Vol.32, No.4, pp. 785-797, 2024, DOI:10.32604/or.2024.047021

Abstract Cytochromes P450 (CYPs) play a prominent role in catalyzing phase I xenobiotic biotransformation and account for about 75% of the total metabolism of commercially available drugs, including chemotherapeutics. The gene expression and enzyme activity of CYPs are variable between individuals, which subsequently leads to different patterns of susceptibility to carcinogenesis by genotoxic xenobiotics, as well as differences in the efficacy and toxicity of clinically used drugs. This research aimed to examine the presence of the CYP2B6*9 polymorphism and its possible association with the incidence of B-CLL in Egyptian patients, as well as the clinical outcome after receiving cyclophosphamide chemotherapy. DNA… More > Graphic Abstract

Yulan Yu^1,2, Rassamee Chotipanvithayakul³, Hujiao Kuang⁴, Wit Wichaidit^3,*, Chonghua Wan^1,2,*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1343-1351, 2023, DOI:10.32604/ijmhp.2023.043446

Abstract Adverse childhood experiences (ACEs) can negatively affect mental health, whereas character strengths seem to be positively correlated with mental health. Detailed information on the history of ACEs among university students in China and the extent which mental health is associated with ACEs and character strengths can contribute to the needed empirical evidence for relevant stakeholders. Objectives of this study are 1) to estimate the prevalence of ACEs among undergraduate students in Southern China; and 2) to assess the extent which mental health outcomes (positive growth, well-being, and depression) are associated with ACEs and character strengths among undergraduate students in Southern… More >

HONGYUAN LIANG^1,#, YANQIU LI^2,#, YONGGANG QU³, LINGYUN ZHANG^4,*

Oncology Research, Vol.32, No.2, pp. 393-407, 2024, DOI:10.32604/or.2023.031134

Abstract Advanced LUAD shows limited response to treatment including immune therapy. With the development of sequencing omics, it is urgent to combine high-throughput multi-omics data to identify new immune checkpoint therapeutic response markers. Using GSE72094 (n = 386) and GSE31210 (n = 226) gene expression profile data in the GEO database, we identified genes associated with lung adenocarcinoma (LUAD) death using tools such as “edgeR” and “maftools” and visualized the characteristics of these genes using the “circlize” R package. We constructed a prognostic model based on death-related genes and optimized the model using LASSO-Cox regression methods. By calculating the cell death… More >

SUKHENDU DEY^1,#, SANDIPAN PAL^2,#, APURBA RATAN GHOSH¹, PALAS SAMANTA^3,*

BIOCELL, Vol.47, No.12, pp. 2579-2590, 2023, DOI:10.32604/biocell.2023.031114

Abstract The process of development is intricate and couple-dependent phenomenon. Accordingly, the study of molecular and cellular biology-based developmental toxicology biomarkers increasingly is becoming an important part of risk assessment and management of chemicals for detection of health outcomes and/or biological endpoint like cytotoxicity, cell death, etc. Since, the evolution of developmental toxicology field a number of tools/markers have been developed or addressed to deal with developmental outcomes, which can ultimately be used for the development of adverse outcome pathways (AOPs) of developmental toxicants. As a result, this paper provides an overview of the current state of developmental toxicology biomarkers and… More >

QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

François-Xavier Van Vyve¹, Karlien Carbonez², Jelena Hubrechts², Geoffroy de Beco¹, Jean E. Rubay¹, Mona Momeni³, Thierry Detaille⁴, Alain J. Poncelet^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 539-550, 2023, DOI:10.32604/chd.2023.042344

Abstract Objectives: Over the last decade, neonatal repair has been advocated for many congenital heart diseases. However, specific subgroups of complex congenital heart disease still require temporary palliation for which both surgical and endovascular techniques are currently available. We reviewed our institutional experience with shunt palliation with an emphasis on risk factors for early mortality. Methods: This is a single-center retrospective study on 175 patients undergoing surgery for central shunt or modified Blalock-Taussig shunt. All data were extracted from a prospectively collected computerized database. We identified risk factors for early mortality by uni- and multi-variable analysis. All data were censored at… More >

François-Xavier Van Vyve^1,#, Karlien Carbonez^2,#, Geoffroy de Beco¹, Stéphane Moniotte², Jean E. Rubay¹, Mona Momeni³, Laurent Houtekie⁴, Alain J. Poncelet^1,*

Congenital Heart Disease, Vol.18, No.5, pp. 525-537, 2023, DOI:10.32604/chd.2023.042341

Abstract Objective: Despite increasing enthusiasm for neonatal repair, patients with ductal-dependent circulation (pulmonary/systemic) or restrictive pulmonary blood flow still require initial palliation. Ductal stenting has emerged as an endovascular approach whereas modified-Blalock-Taussig and central shunt remain surgical references. In this study, we analyzed the relationship between pulmonary artery growth, sites of shunt connection, or antegrade pulmonary blood flow in surgically placed shunts. The need for secondary catheter-based interventions or pulmonary arterioplasty was also investigated. Methods: A retrospective single-center study analyzing 175 patients undergoing surgery for a central or modified-Blalock-Taussig shunt. Outcome growth variables were right pulmonary artery/left pulmonary artery diameters/Z scores,… More > Graphic Abstract

Amy J. Kaye^1,*, Vanessa Prosper², Kathryn Moffa¹, Vanja Pejic¹, Karen Capraro¹, Georgios D. Sideridis¹, Abigail Ross^1,3, Kristine M. Dennery¹, David R. DeMaso¹

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1103-1115, 2023, DOI:10.32604/ijmhp.2023.030185

Abstract The objective of this study was to evaluate the impact of Break Free from Depression (BFFD), a school-based depression awareness curriculum, in comparison to a wait list control group. A total of 13 eighth grade classrooms participated in either an intervention or control group and completed pre-, post-, and three-month follow-up surveys. Students participating in BFFD (N = 6 classrooms, 166 students) demonstrated enhanced knowledge of and more adaptive attitudes towards depression compared to the control group (N = 7 classrooms, 155 students). Participants in the BFFD intervention also demonstrated increases in their confidence in knowing how to seek help… More >

Shota Kawai¹, Takashi Kido^1,*, Yuta Teguri¹, Koji Miwa¹, Tomomitsu Kanaya¹, Yoichiro Ishii², Hisaaki Aoki², Futoshi Kayatani², Sanae Tsumura¹

Congenital Heart Disease, Vol.18, No.4, pp. 399-411, 2023, DOI:10.32604/chd.2023.042243

Abstract Objectives: We sought to determine the long-term outcomes and mortality-associated factors after systemic-to-pulmonary artery shunt (SPS) in patients with heterotaxy syndrome. Methods: We retrospectively analyzed all patients with a functional single ventricle and heterotaxy syndrome who underwent SPS at our center from January 2001 to April 2022. Results: This study involved 84 patients. Restrictive pulmonary blood flow requiring early modulation was presented in 34 (40%) patients. Compared with patients without restrictive pulmonary blood flow (N = 50 [60%]), the postnatal survival of these 34 patients was significantly lower at 10 years (log rank: p = 0.04), but the statistical significance… More >