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  • Open Access

    ARTICLE

    OTUD7B Stabilization by METTL14-Mediated m6A Methylation Drives HIF-1α Expression in Esophageal Squamous Cell Carcinoma

    Fei Ren1,#, Yansen Cai2,#, Yang Song1,*

    Oncology Research, Vol.33, No.8, pp. 2055-2074, 2025, DOI:10.32604/or.2025.061301 - 18 July 2025

    Abstract Objectives: Epigenetic changes, particularly N6-methyladenosine (m6A) modifications, play a pivotal role in cancer development. This study explored the role of ovarian tumor deubiquitinase 7B (OTUD7B) in esophageal squamous cell carcinoma (ESCC) in the context of m6A methylation and the hypoxia-inducible factor-1α (HIF-1α) pathway. Methods: The GSE179267 dataset was used to conduct differential gene expression analysis to identify key m6A-enriched genes. The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Sequence-based RNA Adenosine Methylation Site Predictor (SRAMP) databases were used to evaluate the expression of OTUD7B in ESCC and its correlation with methyltransferase-like 14… More >

  • Open Access

    ARTICLE

    Fully Automatic Segmentation of Gynaecological Abnormality Using a New Viola–Jones Model

    Ihsan Jasim Hussein1, M. A. Burhanuddin2, Mazin Abed Mohammed3,*, Mohamed Elhoseny4, Begonya Garcia-Zapirain5, Marwah Suliman Maashi6, Mashael S. Maashi7

    CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 3161-3182, 2021, DOI:10.32604/cmc.2021.012691 - 28 December 2020

    Abstract One of the most complex tasks for computer-aided diagnosis (Intelligent decision support system) is the segmentation of lesions. Thus, this study proposes a new fully automated method for the segmentation of ovarian and breast ultrasound images. The main contributions of this research is the development of a novel Viola–James model capable of segmenting the ultrasound images of breast and ovarian cancer cases. In addition, proposed an approach that can efficiently generate region-of-interest (ROI) and new features that can be used in characterizing lesion boundaries. This study uses two databases in training and testing the proposed… More >

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