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  • Open Access

    REVIEW

    Pathogenic genes associated with Parkinson’s disease: molecular mechanism overview

    TINGTING LIU1,#, YIWEI HAO2,#, LIFENG ZHAO2,*

    BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130

    Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry other mutation sites that increase… More >

  • Open Access

    REVIEW

    Overview of Jute Fibre as Thermoplastic Matrix Polymer Reinforcement

    Tezara Cionita1,*, Mohammad Hazim Mohamad Hamdan2, Januar Parlaungan Siregar3,4,*, Deni Fajar Fitriyana5, Ramli Junid6, Wong Ling Shing7, Jamiluddin Jaafar8, Agustinus Purna Irawan9, Teuku Rihayat10, Rifky Ismail11, Athanasius Priharyoto Bayuseno11, Emilianus Jehadus12

    Journal of Renewable Materials, Vol.12, No.3, pp. 457-483, 2024, DOI:10.32604/jrm.2024.045814

    Abstract Recent decades have seen a substantial increase in interest in research on natural fibres that is aligned with sustainable development goals (SDGs). Due to their renewable resources and biodegradability, natural fiber-reinforced composites have been investigated as a sustainable alternative to synthetic materials to reduce the usage of hazardous waste and environmental pollution. Among the natural fibre, jute fibre obtained from a bast plant has an increasing trend in the application, especially as a reinforcement material. Numerous research works have been performed on jute fibre with regard to reinforced thermoset and thermoplastic composites. Nevertheless, current demands on sustainable materials have required… More >

  • Open Access

    REVIEW

    Sustainable Biocomposites Materials for Automotive Brake Pad Application: An Overview

    Joseph O. Dirisu1,*, Imhade P. Okokpujie2,3,*, Olufunmilayo O. Joseph1, Sunday O. Oyedepo1, Oluwasegun Falodun4, Lagouge K. Tartibu3, Firdaussi D. Shehu1

    Journal of Renewable Materials, Vol.12, No.3, pp. 485-511, 2024, DOI:10.32604/jrm.2024.045188

    Abstract Research into converting waste into viable eco-friendly products has gained global concern. Using natural fibres and pulverized metallic waste becomes necessary to reduce noxious environmental emissions due to indiscriminately occupying the land. This study reviews the literature in the broad area of green composites in search of materials that can be used in automotive brake pads. Materials made by biocomposite, rather than fossil fuels, will be favoured. A database containing the tribo-mechanical performance of numerous potential components for the future green composite was established using the technical details of bio-polymers and natural reinforcements. The development of materials with diverse compositions… More > Graphic Abstract

    Sustainable Biocomposites Materials for Automotive Brake Pad Application: An Overview

  • Open Access

    REVIEW

    An overview of autophagy in the differentiation of dental stem cells

    XITONG ZHAO, TIANJUAN JU, XINWEI LI, CHANGFENG LIU, LULU WANG*, LI-AN WU*

    BIOCELL, Vol.48, No.1, pp. 47-64, 2024, DOI:10.32604/biocell.2023.045591

    Abstract Dental stem cells (DSCs) have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response. These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine. While many regulatory factors determine the differentiation trajectory of DSCs, prior research has predominantly been based on genetic, epigenetic, and molecular aspects. Recent evidence suggests that DSC differentiation can also be influenced by autophagy, a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions. This comprehensive review endeavors to elucidate… More >

  • Open Access

    REVIEW

    An Overview of ETL Techniques, Tools, Processes and Evaluations in Data Warehousing

    Bilal Khan1, Saifullah Jan1,*, Wahab Khan1, Muhammad Imran Chughtai2

    Journal on Big Data, Vol.6, pp. 1-20, 2024, DOI:10.32604/jbd.2023.046223

    Abstract The extraction, transformation, and loading (ETL) process is a crucial and intricate area of study that lies deep within the broad field of data warehousing. This specific, yet crucial, aspect of data management fills the knowledge gap between unprocessed data and useful insights. Starting with basic information unique to this complex field, this study thoroughly examines the many issues that practitioners encounter. These issues include the complexities of ETL procedures, the rigorous pursuit of data quality, and the increasing amounts and variety of data sources present in the modern data environment. The study examines ETL methods, resources, and the crucial… More >

  • Open Access

    REVIEW

    An Overview of Sequential Approximation in Topology Optimization of Continuum Structure

    Kai Long1, Ayesha Saeed1, Jinhua Zhang2, Yara Diaeldin1, Feiyu Lu1, Tao Tao3, Yuhua Li1,*, Pengwen Sun4, Jinshun Yan5

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 43-67, 2024, DOI:10.32604/cmes.2023.031538

    Abstract This paper offers an extensive overview of the utilization of sequential approximate optimization approaches in the context of numerically simulated large-scale continuum structures. These structures, commonly encountered in engineering applications, often involve complex objective and constraint functions that cannot be readily expressed as explicit functions of the design variables. As a result, sequential approximation techniques have emerged as the preferred strategy for addressing a wide array of topology optimization challenges. Over the past several decades, topology optimization methods have been advanced remarkably and successfully applied to solve engineering problems incorporating diverse physical backgrounds. In comparison to the large-scale equation solution,… More >

  • Open Access

    REVIEW

    An Overview of Modern Cartographic Trends Aligned with the ICA’s Perspective

    Maan Habib1,*, Maan Okayli2

    Revue Internationale de Géomatique, Vol.32, pp. 1-16, 2023, DOI:10.32604/rig.2023.043399

    Abstract This study provides a comprehensive overview of modern cartography innovations and emerging trends, highlighting the importance of geospatial representation in various fields. It discusses recent advancements in geospatial data collection techniques, including satellite and aerial imagery, Light Detection and Ranging (LiDAR) technology, and crowdsourcing. The research also investigates the integration of big data, machine learning, and real-time processing in Geographic Information Systems (GIS), as well as advances in geospatial visualization. In addition, it examines the role of cartography in addressing global challenges such as climate change, disaster management, and urban planning in line with the International Cartographic Association’s (ICA) perspectives.… More >

  • Open Access

    ARTICLE

    An Overview of Seismic Risk Management for Italian Architectural Heritage

    Lucio Nobile*

    Structural Durability & Health Monitoring, Vol.17, No.5, pp. 353-368, 2023, DOI:10.32604/sdhm.2023.028247

    Abstract The frequent occurrence of seismic events in Italy poses a strategic problem that involves either the culture of preservation of historical heritage or the civil protection action aimed to reduce the risk to people and goods (buildings, bridges, dams, slopes, etc.). Most of the Italian architectural heritage is vulnerable to earthquakes, identifying the vulnerability as the inherent predisposition of the masonry building to suffer damage and collapse during an earthquake. In fact, the structural concept prevailing in these ancient masonry buildings is aimed at ensuring prevalent resistance to vertical gravity loads. Rarely do these ancient masonry structures offer relevant resistance… More >

  • Open Access

    REVIEW

    Research Progress on the Influence of Varying Fiber Contents on Mechanical Properties of Recycled Concrete

    Zhenqing Shi1, Guomin Sun1, Jianyong Pang2,*

    Structural Durability & Health Monitoring, Vol.17, No.3, pp. 239-255, 2023, DOI:10.32604/sdhm.2023.022816

    Abstract Applying recycled concrete for engineered projects not only protects the ecological environment but also improves the utilization rate of waste concrete to satisfy sustainable development requirements. However, the mechanical properties of recycled concrete are not as good as those of ordinary concrete. To enhance the former’s performance and increase its popularity and application in engineering fields, notable advances have been made by using steel, synthetic, plant, and mineral fiber materials. These materials are added to recycled concrete to improve its mechanical properties. Studies have shown that (1) steel fibers have a distinct reinforcing effect and improve the strength, toughness, and… More >

  • Open Access

    REVIEW

    A broad overview of genotype imputation: Standard guidelines, approaches, and future investigations in genomic association studies

    MIRKO TRECCANI*, ELENA LOCATELLI, CRISTINA PATUZZO, GIOVANNI MALERBA*

    BIOCELL, Vol.47, No.6, pp. 1225-1241, 2023, DOI:10.32604/biocell.2023.027884

    Abstract The advent of genomic big data and the statistical need for reaching significant results have led genome-wide association studies to be ravenous of a huge number of genetic markers scattered along the whole genome. Since its very beginning, the so-called genotype imputation served this purpose; this statistical and inferential procedure based on a known reference panel opened the theoretical possibility to extend association analyses to a greater number of polymorphic sites which have not been previously assayed by the used technology. In this review, we present a broad overview of the genotype imputation process, showing the most known methods and… More >

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