Berengere PAPEGAY1, *, Michaela STADLER1, Vincent Nuyens1, Isabelle SALMON2, Veronique KRUYS3, Jean G. BOOGAERTS1
BIOCELL, Vol.38, No.1, pp. 25-32, 2014, DOI:10.32604/biocell.2014.38.025
Abstract Ischemia-reperfusion injury is a determinant in liver injury occurring during surgery, ischemic
states and multiple organ failure. The pre-existing nutritional status of the liver, i.e., fasting, might contribute to
the extent of tissue injury. This study investigated whether alanine, an amino acid precursor of glucose, could
protect ex vivo perfused livers of fasting rats from reperfusion injury. The portal vein was cannulated, the liver removed and perfused in a closed ex vivo system. Isolated livers were perfused either with glucose 1 g/L and 10 g/L,
or with equal concentrations of alanine (n = 10 in each group). The experiment consisted… More >
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